The Tumor Microenvironment

Rebecca Bagley is a senior scientist at Genzyme Corporation and has worked in the biotechnology industry for 20 years with degrees in biology from Wellesley College and Harvard University. Her expertise in drug development spans a wide range of approaches including immunotherapies, gene and protein therapies, and small molecule delivery with publications in journals such as Molecular Cancer Therapeutics, Cancer Research, and Microvascular Research . Her current research focuses on stem cells, tumor vasculature, and target validation.

Physiological Parameters.- Combination Strategies Targeting Hypoxia Inducible Factor 1 (HIF-1) for Cancer Therapy.- The Tumor Microenvironment: New Insights into Regulation of Tumor pH by Carbonic Anhydrases.- Hypoxia, Gene Expression, and Metastasis.- Molecular Mechanisms Regulating Expression and Function of Cancer-Associated Carbonic Anhydrase IX.- Glycolytic Pathway as a Target for Tumor Inhibition.- Malignant Cells.- Aberrant DNA Methylation in Cancer Cells.- DNA Repair and Redox Signaling.- Cancer Stem Cells and Microenvironment.- Epithelial–Mesenchymal Transition in Development and Diseases.- Invasion and Metastasis.- Dormancy of Disseminated Tumor Cells: Reciprocal Crosstalk with the Microenvironment.- Vasculature And Stroma.- Impact of Endothelial Progenitor Cells on Tumor Angiogenesis and Outcome of Antiangiogenic Therapy: New Perspectives on an Ongoing Controversy.- Bone Marrow Derived Mesenchymal Stem/Stromal Cells and Tumor Growth.- Integrin Signaling in Lymphangiogenesis.- Role of Pericytes in Resistance to Antiangiogenic Therapy.- Tumour-Promoting Stromal Myofibroblasts in Human Carcinomas.- Immune-Mediated Cells.- Mast Cells and Tumor Microenvironment.- Macrophages in the Tumor Microenvironment.- The Prognostic Significance of Tumor-Infiltrating Lymphocytes.- The Pro-inflammatory Milieu and Its Role in Malignant Epithelial Initiation.- Natural Killer Cells for Adoptive Immunotherapy.- Extracellular Matrix.- Fibronectin.- Collagen in Cancer.- Integrins and Cancer.- Matrix Metalloproteinases and Cancer Cell Invasion/Metastasis.- Tetraspanins and Cancer Metastasis.- Secreted Proteins.- Chemokines and Metastasis.- Transforming Growth Factor-? in Lung Cancer, Carcinogenesis, and Metastasis.- Cooperative Interactions Between Integrins and Growth FactorSignaling in Pathological Angiogenesis.- The Extracellular Matrix and the Growth and Survival of Tumors.- Secreted Growth Factors as Therapeutic Targets.- Adrenomedullin.