Pulmonary Circulation

Andrew J Peacock - Professor of Medicine, Consultant Respiratory Physician and Director, Scottish Pulmonary Vascular Unit, Regional Heart and Lung Centre,Golden Jubilee National Hospital, Glasgow, UK Robert Naeije - Professor of Physiology and Medicine, and Consultant at the Department of Cardiology of the Erasme Academic Hospital of the Free University of Brussels, Belgium Lewis J Rubin - Emeritus Professor of Medicine and Emeritus Director, Pulmonary Vascular Center at the University of California, San Diego School of Medicine, La Jolla, CA, USA

The Function of the Normal Pulmonary Circulation & Right Heart
Pulmonary vascular function
Right heart function

Pathophysiology & Pathology of Pulmonary Vascular Disease
Pathology of pulmonary vascular disease
Hypoxic pulmonary vasoconstriction and hypertension
Pulmonary vascular remodeling & pathobiology of pulmonary hypertension

Clinical Assessment of Pulmonary Hypertension: Diagnosis & Management
Clinical features
Imaging: Echocardiography
Imaging: Chest radiography, ventilation/perfusions cintigraphy and computed tomography
Imaging: Emerging modalities (MR , PET and others)
Exercise testing and pulmonary hypertension: Six minute walk testing and cardiopulmonary exercise testing
Blood biomarkers
Cardiac catheterisation of patients with pulmonary hypertension
An integrated approach to the diagnosis and clinical management of pulmonary hypertension

Disorders Associated with Pulmonary Hypertension
Classification and clinical features of pulmonary hypertension
Idiopathic and heritable pulmonary hypertension: Introduction to pathophysiology & clinical aspects
Genetics of pulmonary arterial hypertension
Pulmonary hypertension related to appetite suppressants
Pulmonary hypertension associated with portal hypertension
Pulmonary arterial hypertension related to HIV infection
Pulmonary hypertension associated with congenital systemic to pulmonary shunts
Hemolysis-associated pulmonary hypertension in sickle cell disease and thalassemia
Pulmonary hypertension in pregnancy

Drug and Non Drug Treatment of Pulmonary Hypertension
Conventional medical therapies: general measures, supportive treatments and calcium channel blockers
Prostacyclins: intravenous, subcutaneous, inhaled and oral
Inhaled nitric oxide and nitric oxide donors
Endothelin receptor antagonists
The nitric oxide and cyclic guanosine monophosphate pathway
Combination therapy for pulmonary arterial hypertension
Stem cell therapy
Novel antin-proliferative strategies

Surgical Treatment of Pulmonary Hypertension
Lung transplantation
Atrial septostomy and other interventional procedures
Pulmonary endarterectomy
An integrated approach to the treatment of pulmonary arterial hypertension

Pulmonary Hypertension due to Capillary or Post Capillary disease
Pulmonary hypertension secondary to left heart failure
Pulmonary veno-occlusive disease
Pulmonary capillary hemangionmatosis

Pulmonary Hypertension Associated with Disorders of the Respiratory System and/or Hypoxemia
Pulmonary hypertension due to chronic hypoxic lung disease COPD and ILD
Pulmonary circulation in obstructive sleep apnea
An integrated approach to treatment of pulmonary hypertension due to hypoxic lung disease

Other Important Causes of Pulmonary Hypertension
Schistosomiasis

Acute and Chronic Pulmonary Thromboembolism, Pulmonary Vascular Tumors and Pulmonary Vasculitis.
Diagnosis of acute pulmonary thromboembolism
Treatment of acute pulmonary thromboembolism
Chronic thromboembolic pulmonary hypertension
Pulmonary vascular tumors
Pulmonary vasculitis

Pulmonary Hypertension in Pediatrics
Idiopathic pulmonary arterial hypertension in children

Pulmonary Circulation in Critical Care
Effects of mechanical ventilation on the pulmonary circulation
Effects of lung injury on the pulmonary circulation
Pharmacological management of the pulmonary circulation in critically ill patients

Pulmonary Circulation in Special Environments
High altitude pulmonary hypertension
High altitude pulmonary oedema
Pulmonary circulation in the underwater environment

Disorders Causing Intrapulmonary Shunt
Hepatopulmonary syndrome
Pulmonary arteriovenous malformations