Models of Cellular Regulation

Baltazar Aguda is currently associate professor of Genetics & Genomics at the Boston University School of Medicine. He holds joint appointments in Biomedical Engineering, in the Bioinformatics & Systems Biology program at Boston University, and a membership in the Center for Biodynamics in the same university. Recently, he was appointed member of the National Science Foundation's (NSF, USA) research proposal review panel in molecular & cellular biosciences (2004-7). He was a visiting faculty at the Mathematical Biosciences Institute at Ohio State University (2003), at the Weizmann Institute of Science in Israel (2000), and a visiting associate at the California Institute of Technology (2000-2001). Dr. Aguda obtained his PhD in Chemistry (Chemical Physics Program) from the University of Alberta in Canada (1986), and was a tenured faculty member of the Department of Chemistry & Biochemistry at Laurentian University in Canada (1994-2002) before moving to Boston. Avner Friedman is a Distinguished Professor of Mathematics and Physical Sciences at the Ohio State University, where he also serves as the Director of the Mathematical Biosciences Institute. He received his Ph.D. degree in 1956 from the Hebrew University. He was Professor of Mathematics at Northwestern University (1962-1985), and a Duncan Distinguished Professor of Mathematics at Purdue University (1985-1987).

1. General Introduction ; 2. From Molecules to a Living Cell ; 3. Mathematical and Computational Modeling Tools ; 4. Gene regulatory networks: from DNA to metabolites and back ; 5. Control of DNA replication in a prokaryote ; 6. The Eukaryotic Cell Cycle Engine ; 7. Cell Cycle Control ; 8. Cell Death ; 9. Cell Differentiation ; 10. Cell Aging and Renewal ; 11. Multiscale Modeling of Cancer