50 Years of DNA

BRUCE ALBERTS, National Academy of Sciences, Washington, USA PHILIP BALL JOHN BELL, University of Oxford, UK ZEV BRYANT, Department of Molecular Cell Biology, University of California, USA CARLOS BUSTAMANTE, Department of Molecular and Cell Biology and Department of Physics at Howard Hughes Medical Institute, University of California, USA ARAVINDA CHAKRAVARTI , McKusick-Nathans Institute of Genetic Medicine, John Hopkins University School of Medicine, Baltimore, USA GARY FELSENFELD, Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, USA ERROL FRIEDBERG, Laboratory of Molecular Pathology, University of Texas Southwestern Medical Center, USA DAVID GALAS, Keck Graduate Institute of Applied Sciences, USA MARK GROUDINE, Fred Hutchinson Cancer Research Center, Washington USA LEROY HOOD, Institute for Systems Biology, Seattle, USA MARTIN KEMP, Department of the History of Art, University of Oxford and Wallace Kemp, London, UK PETER LITTLE, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Australia BRENDA MADDOX MACLYN MCCARTY, Rockefeller University, USA GUSTAV NOSSAL, Department of Pathology, The University of Melbourne, Australia ROBERT OLBY, Department of History and Philosophy of Science, University of Pittsburgh, USA SVANTE PÄÄBO, Max Plank Institute for Evolutionary Anthropology, Leipzig, Germany NADRIAN SEEMAN, Department of Chemistry, New York University,USA STEVEN SMITH, Department of Physics and Howard Hughes Medical Institute, University of California, USA

Foreword Remarks from Phil Campbell Preface; J.Clayton & C.Dennis PART I: HISTORY On the Shoulders of Giants : The Quest to Solve DNA? 1953 Revisited What Happened Next: The Golden Years of Molecular Biology PART II: THE PRESENT Where AreThey Now? Structural Biology: Still Going Strong Genomes Galore Window on Evolution 'Artificial Evolution': Maize, Wheat, Rice Domestication PART III: THE FUTURE DNA as a Tool in Disease Diagnosis and Therapy DNA and Culture The Genie's Out PART IV: THE DOUBLE HELIX - 50 YEARS The Eternal Molecule; C.Dennis &P.Campbell PART V: FACSIMILE PAPERS FROM NATURE , 25 APRIL 1953 A Structure for Deoxyribose Nucleic Acid ( Nature 171, 737-738; 1953); J.D.Watson & F.H.C.Crick Molecular Structure of Deoxypentose Nucleic Acids ( Nature 171, 738-740; 1953); M.H.F.Wilkins, A.R.Stokes & H.R.Wilson Molecular Configuration in Sodium Thymonucleate ( Nature 171, 740-741; 1953), R.E.Franklin & R.G.Gosling HISTORICAL BACKGROUND Quiet Debut for the Double Helix; R.Olby Discovering Genes are Made of DNA; M.McCarty DNA and the 'Wronged Heroine'; B.Maddox PART VI: DNA IN MEDICINE AND SOCIETY The Mosaic That is Our Genome; S.Pääbo Nature, Nurture and Human Disease; A.Chakravarti & P.Little The Double Helix in Clinical Practice; J.I.Bell The Mona Lisa of Modern Science; M.Kemp PART VII: DNA: THE BIOLOGICAL MOLECULE Portrait of a Molecule; P.Ball Ten Years of Tension: Single-Molecule DNA Mechanics; C.Bustamante, Z.Bryant & S.B.Smith DNA in a Material World; N.C.Seeman DNA Replication and Recombination; B.Alberts DNA Damage and Repair; E.C.Freidberg The Double Helix and Immunology; G.J.V.Nossal The Digital Code of DNA; L.Hood & D.Galas Controlling the Double Helix; G.Felsenfeld & M.Groudine