Clinical Precision Medicine

Dr. Crabtree received her PhD in Biochemistry from the University of Oklahoma where she was instrumental in sequencing portions of human chromosomes 9, 11 and 22 as part of the Human Genome Project. Her graduate work led to the identification of the gene for Multiple Endocrine Neoplasia, type 1 and she studied the mechanisms of endocrine tumor biology as a Postdoctoral Fellow at the National Human Genome Research Institute, National Institutes of Health under the direction of Dr. Francis Collins. Dr. Crabtree developed the first mouse models of MEN1, characterizing the endocrine pancreatic and parathyroid phenotypes associated with this disease model system. The study of endocrine tumor biology led to a position with Wyeth Pharmaceuticals Research and Development where she established a successful platform for drug development in uterine fibroids and developed mouse model systems to analyze tissue specific estrogenic compounds (TSECs) and androgenetic alopecia. She joined the LSUHSC Department of Genetics in 2009 to study pancreatic biology focusing on the mechanisms of pancreatic islet adaptation in diabetes, obesity and pregnancy as well as mechanisms of neuroendocrine tumorigenesis. Dr. Crabtree has published over 35 publications and was the recipient of the John Haddad Young Investigator Award from AIMM-ASBMR for her work on MEN1.

1. Chromosomes and Chromosomal Abnormalities 2. Molecular Genetics 3. Epigenetic Regulation 4. Heredity 5. Clinical Genetics 6. Pharmacogenomics 7. Immunogenomics