Advanced LIMS Technology

1 LIMS: An automating or informating technology?.- 1.1 Introduction.- 1.2 Current LIMS fail to meet business requirements.- 1.3 Current LIMS automate data management functions.- 1.4 New LIMS will informate, not automate.- 1.5 Architecture of an informating system.- 1.6 Making IT happen.- References.- 2 A model for a comprehensive LIMS.- 2.1 Introduction.- 2.2 Strategic design of a LIMS.- 2.3 What is a LIMS?.- 2.4 An architecture for a comprehensive LIMS.- 2.5 A LIMS model.- 2.6 Definition of a LIMS.- 2.7 Detailed classification of LIMS functions.- 2.8 Applying the LIMS model: the selection of a commercial LIMS.- 2.9 LIMS standards.- 2.10 Summary.- References.- 3 LIMS in a forensic laboratory.- 3.1 Introduction.- 3.2 Objectives of a LIMS.- 3.3 The system.- 3.4 The future.- 3.5 Conclusions.- Acknowledgement.- 4 Application of a LIMS in a pharmaceutical drug metabolism and pharmacokinetics laboratory.- 4.1 Introduction.- 4.2 Study objectives in drug metabolism and pharmacokinetics.- 4.3 Configuration of the database.- 4.4 LabManager in use.- 4.5 The future.- References.- 5 Use of protocol-synchronous LIMS structures to expand the role of the centralized clinical trial laboratory in pharmaceutical research.- 5.1 Introduction.- 5.2 The expanding role of the central laboratory in pharmaceutical research.- 5.3 Comparing traditional and protocol-synchronous LIMS structures in the clinical trial laboratory.- 5.4 Defining protocol-driven time and events using a multidimensional matrix.- 5.5 Managing protocol-driven time and events using matrix-dependent control structures.- 5.6 Managing protocol-driven time and events using matrix-dependent output structures.- 5.7 Summary.- 6 Medical Laboratory Information Systems (LIS).- 6.1 History of clinical laboratory computerization.- 6.2 Computerization and automation of the ‘testing process’.- 6.3 How computers function in the clinical laboratory.- 6.4 Acquisition of a LIS.- 6.5 Future of laboratory information systems.- References.- 7 EPA’s Relational Laboratory Information Management System: Development and implementation.- 7.1 Introduction.- 7.2 Development.- 7.3 Implementation.- 7.4 Conclusions.- References.- 8 LIMS to robotics interface: A practical approach.- 8.1 Introduction.- 8.2 The case for automation.- 8.3 Role of a Laboratory Information Management System.- 8.4 Sample planning and scheduling.- 8.5 Auditability.- 8.6 Information transferred via the interfaces.- 8.7 Laboratory Information Management System network.- 8.8 Analytical process automation.- 8.9 Impact on the laboratory working environment.- References.- 9 Interfacing the real world to LIMS.- 9.1 Introduction.- 9.2 The analysis procedure.- 9.3 Beckman.- 9.4 Hewlett Packard.- 9.5 LabSystems (Fisons Instruments).- 9.6 The future.- Acknowledgements.- 10 Replacement LIMS: Moving forward or maintaining the status quo.- 10.1 Introduction.- 10.2 Why change?.- 10.3 Why not change?.- 10.4 How long should a LIMS last?.- 10.5 How do you justify a replacement LIMS?.- 10.6 Would a custom system be better?.- 10.7 Support your vendor.- 10.8 How to implement a replacement LIMS.- 11 The promise of client—server LIMS applications.- 11.1 Introduction.- 11.2 Review of LIMS development over the last ten years — the story so far.- 11.3 Current trends.- 11.4 Regulatory requirements.- 11.5 Standards for systems analysis and construction of information systems.- 11.6 Understanding the user.- 11.7 Meeting the requirements with appropriate technology: The challenge facing client-server technology.- 11.8 Discussion of relationships and issues.- 11.9Systems analysis, construction of information systems and process re-engineering.- 11.10 Software development.- 11.11 Communications.- 11.12 Implementing client-server technology.- 11.13 Conclusions.- 11.14 The way forward?.- References.- 12 Standards for analytical laboratory data communications, storage, and archival.- 12.1 Introduction.- 12.2 Standards investment and payback.- 12.3 The ADISS Program.- 12.4 Application of the ADISS Information Model to chromatography.- 12.5 Future ADISS extensions for chromatography and other techniques.- 12.6 Future influence of ADISS standards on LIMS in R&D.- 12.7 The influence of standards on market dynamics.- 12.8 Summary and recommendations.- Note.- References.