Handbook of the Biology of Aging

Dr. Nicolas Musi is a tenured Professor of Medicine (Division of Geriatrics and Gerontology and Division of Diabetes) and Director of the Barshop Institute for Longevity and Aging Studies, the San Antonio Claude D. Pepper Older Americans Independence Center, and the San Antonio Geriatric Research, Education and Clinical Center. He is an active educator and research mentor, and supervises clinical and research fellows, residents and graduate students. In this role, he also functions as Director of a T32 Training Grant on the Biology of Aging. Dr. Peter Hornsby obtained a Ph.D. in Cell Biology at the Institute of Cancer Research of the University of London. He has held faculty positions at the University of California SanDiego, the Medical College of Georgia, and Baylor College of Medicine. Currently he is Professor in Department of Physiology and Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio.

Part I: Basic mechanisms, underlying physiological changes, model organisms and interventions

1. Longevity as a complex genetic trait

2. DNA damage and repair in aging

3. Mechanisms of cell senescence in aging

4. The nature of aging and the geroscience hypothesis

5. Sirtuins, healthspan, and longevity in mammals

6. Integrative genomics of aging

7. Thermogenesis and aging

8. Yeast as a model organism for aging research

9. Model organisms (invertebrates)

10. NIA Interventions Testing Program: A collaborative approach for investigating interventions to promote healthy aging

11. Aging in nonhuman primates

Part II: Organ systems in humans and other animals, human health and longevity

12. Senotherapeutics: Experimental therapy of cellular senescence

13. The role of neurosensory systems in the modulation of aging

14. Aging of the sensory systems: hearing and vision disorders

15. Cardiac aging

16. The aging immune system: Dysregulation, compensatory mechanisms, and prospects for intervention

17. Microbiome changes in aging

18. Lipidomics of aging

19. Trends in morbidity, healthy life expectancy, and the compression of morbidity