Thyroid Cancer -

Thyroid Cancer (eBook)

A Comprehensive Guide to Clinical Management
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2016 | 3rd ed. 2016
XXXI, 1049 Seiten
Springer New York (Verlag)
978-1-4939-3314-3 (ISBN)
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Thoroughly revised and extensively expanded, this encyclopedic, highly acclaimed title addresses all aspects of the etiology, pathogenesis, diagnosis, initial treatment and long-term management of all varieties of thyroid cancer. Expertly edited by Drs. Leonard Wartofsky and Douglas Van Nostrand, this gold standard reference is divided into 11 Parts: General Considerations on Thyroid Cancer; General Considerations on Nuclear Medicine; the Thyroid Nodule; Well-Differentiated Thyroid Cancer; Variants of Thyroid Cancer, Undifferentiated Tumors: Medullary Thyroid Carcinoma; Undifferentiated Tumors: Thyroid Lymphoma; Undifferentiated Tumors: Anaplastic Thyroid Cancer; New Frontiers and Future Directions; and Additional Resources. With exceptional breadth and depth, the book includes chapters dedicated to isotopes, isotope uptake and scanning procedures such as SPECT/CT, radioiodine ablation (with or without recombinant human TSH), stunning, dosimetry (with or without recombinant human TSH), Octreotide and FDG-PET scanning and other alternative imaging modalities. There is a valuable reference atlas of scan images and illustrations, and a scholarly summary of the side effects of radioiodine and how to avoid or minimize adverse effects of treatment. In addition to an updated section on ultrasonography of the thyroid gland, new sections have been added, including ones on ultrasonography of cervical lymph nodes and imaging for thyroid cancer employing computerized tomography (CT), positron emission tomography (PET) and magnetic resonance imaging (MRI). An indispensable reference source with chapters written by the field's leading authoritative experts, Thyroid Cancer: A Comprehensive Guide to Clinical Management, Third Edition, will be of great interest to not only pathologists, endocrine surgeons, endocrinologists, nuclear medicine physicians, and oncologists but all clinicians with an interest in thyroid cancer. 



Leonard Wartofsky, MD, MACP

Department of Medicine

Washington Hospital Center

Washington, DC, USA

 

Douglas Van Nostrand, MD, FACP, FACNM

Nuclear Medicine

Washington Hospital Center

Washington, DC, USA



Thoroughly revised and extensively expanded, this encyclopedic, highly acclaimed title addresses all aspects of the etiology, pathogenesis, diagnosis, initial treatment and long-term management of all varieties of thyroid cancer. Expertly edited by Drs. Leonard Wartofsky and Douglas Van Nostrand, this gold standard reference is divided into 11 Parts: General Considerations on Thyroid Cancer; General Considerations on Nuclear Medicine; the Thyroid Nodule; Well-Differentiated Thyroid Cancer; Variants of Thyroid Cancer, Undifferentiated Tumors: Medullary Thyroid Carcinoma; Undifferentiated Tumors: Thyroid Lymphoma; Undifferentiated Tumors: Anaplastic Thyroid Cancer; New Frontiers and Future Directions; and Additional Resources. With exceptional breadth and depth, the book includes chapters dedicated to isotopes, isotope uptake and scanning procedures such as SPECT/CT, radioiodine ablation (with or without recombinant human TSH), stunning, dosimetry (with or without recombinant human TSH), Octreotide and FDG-PET scanning and other alternative imaging modalities. There is a valuable reference atlas of scan images and illustrations, and a scholarly summary of the side effects of radioiodine and how to avoid or minimize adverse effects of treatment. In addition to an updated section on ultrasonography of the thyroid gland, new sections have been added, including ones on ultrasonography of cervical lymph nodes and imaging for thyroid cancer employing computerized tomography (CT), positron emission tomography (PET) and magnetic resonance imaging (MRI). An indispensable reference source with chapters written by the field's leading authoritative experts, Thyroid Cancer: A Comprehensive Guide to Clinical Management, Third Edition, will be of great interest to not only pathologists, endocrine surgeons, endocrinologists, nuclear medicine physicians, and oncologists but all clinicians with an interest in thyroid cancer.

Leonard Wartofsky, MD, MACPDepartment of MedicineWashington Hospital CenterWashington, DC, USA Douglas Van Nostrand, MD, FACP, FACNMNuclear MedicineWashington Hospital CenterWashington, DC, USA

PART I. General Considerations  I :  THYROID CANCER1 Anatomy and Physiology of the thyroid gland: Clinical Correlates to Thyroid Cancer2 Epidemiology of Thyroid Cancer3 Molecular Pathogenesis of Thyroid Cancer & Oncogenes in Thyroid Cancer4 Molecular Aspects of Thyroid Cancer in Children5 The Role of Genetics in the Development of Familial Non-Medullary Thyroid Cancer6 Apoptosis in Thyroid Cancer7 Radiation-Induced Thyroid Cancer8 Classification of Thyroid Malignancies9 Staging of Thyroid Cancer10 Recombinant human Thyrotropin (Thyrogen®)PART II. GENERAL CONSIDERATIONS II:  NUCLEAR MEDICINE11 Radioiodine Whole Body Imaging12 Primer and Atlas for the Interpretation of Radioiodine Whole-Body Scintigraphy13 False-Positive Radioiodine-131 scans in Thyroid Cancer14 The Utility of SPECT-CT in Differentiated Thyroid Cancer15 Radioiodine scintigraphy with SPECT/CT: an important diagnostic tool for staging and risk stratification.16 Stunning by 131I scanning: Untoward Effect of 131I Thyroid Imaging Prior to Radioablation Therapy17 Stunning is Not a Problem18 Stunning: Does it Exist? A Commentary19 To Perform or Not to Perform Radioiodine Scans Prior to 131I Remnant Ablation?PART III. THE THYROID NODULE20 The Thyroid Nodule: Evaluation, Risk of Malignancy, and Management 21 Fine-Needle Aspiration22 Diagnostic and Prognostic Molecular Markers in Thyroid Cancer 23 Ultrasonic Imaging of the Thyroid Gland24 Radionuclide Imaging of Thyroid Nodules25 18F Fluoro-deoxyglucose PET and Thyroid Nodules26 Thyroid Nodules and Cancer Risk: Surgical Management27 Thyroid Nodules in Children and Cancer Risk28 Management of the Thyroid Nodule: A Comparison Of Published International GuidelinesPART IV. WELL-DIFFERENTIATED THYROID CANCER A: PAPILLARY CARCINOMA: PRESENTATION29 Papillary Carcinoma: Clinical Aspects 30 Papillary Microcarcinoma31 Surgical Approach to Papillary Thyroid Cancer32 Papillary Carcinoma: Cytology and Pathology                             B.  INITIAL MANAGEMENT33 Remnant Ablation, Adjuvant Treatment and Treatment of Locoregional Metastases with 131I34 Thyroid Remnant Radioiodine Ablation with Recombinant Human ThyrotropinC.  SURVEILLANCE35 Follow-up Strategy in Papillary Thyroid Cancer36 Thyroid Hormone Therapy and Thyrotropin Suppression 37 Thyroglobulin for Differentiated Thyroid Cancer: Measurement and Interferences38 Thyroglobulin Antibodies and Their Measurement39 Diagnosis of Recurrent Thyroid Cancer in Patients with Anti-Thyroglobulin Antibodies40 Ultrasound of the neck lymph nodes 41 Surveillance Radioiodine Whole Body Scans42 Radionuclide Imaging and Treatment of Children with Thyroid Cancer43 Positron Emission Tomography-/Computed Tomography (PET-CT and PET) in Well-Differentiated Thyroid Cancer44 Alternative Thyroid Imaging 45 MR and CT Imaging of Thyroid Cancer46 Thyroglobulin in Lymph Node Aspirate47 Management of the Patients with Negative Radioiodine Scan and Elevated Serum Thyroglobulin48 Prognosis in Papillary Thyroid Cancer 49 Surgical Management of Lymph Node Metastases50 Utility of Second Surgery for Lymph Node Metastases51 Papillary Cancer Special Aspects in Children52 Special Presentations of Thyroid Cancer in Thyrotoxicosis, Renal Failure, and Struma Ovarii 53 Thyroglossal Duct Carcinoma54 Thyroid Cancer in PregnancyD. TREATMENT55 Radiation and Radioactivity56 131I Treatment of Distant Metastases57 Treatment of Metastatic Thyroid Cancer with Radioiodine following preparation by Recombinant Human Thyrotopin58 Dosimetrically-Determined Prescribed Activity of 131I for the Treatment of Metastatic Differentiated Thyroid Carcinoma59 Simplified Methods of Dosimetry60 Radioiodine Dosimetry with Recombinant human Thyrotropin   61 The Use of Lithium as an Adjuvant to Radioiodine In the Treatment of Thyroid Cancer 62 Side Effects of 131I for Therapy of Differentiated Thyroid Carcinoma 63 Radiation Therapy in Papillary Carcinoma64 Chemotherapy of Thyroid Cancer: General Principles65 Bone Metastases from Differentiated Thyroid Carcinoma66 A Summary of Rare Sites of Metastasis Secondary to Differentiated Thyroid Cancer67 Adjunctive Local Approaches to Thyroid Nodules and Metastatic Thyroid Cancer68 Radioiodine-Refractory Thyroid Cancer: Restoring Response to Radioiodine Therapy69 Alternative and Complementary Treatment of Thyroid Disorders                        PART V. WELL-DIFFERENTIATED THYROID CANCER  FOLLICULAR CARCINOMA70 Follicular Thyroid Carcinoma71 Surgical Management of Follicular Cancer72 Pathology of Follicular Cancer73 Hürthle Cell Carcinoma 74 Follow-Up Strategy in Follicular Thyroid Cancer75 Radionuclide Imaging and 131I Therapy in Follicular Thyroid Carcinoma76 PET/CT in Follicular Cancer Including Hürthle Cell Cancer77 Follicular Thyroid Cancer: Special Aspects in Children and Adolescents78 External Radiation Therapy of Follicular Carcinoma79 Determinants of Prognosis of Follicular Thyroid CarcinomaPART VI. VARIANTS OF THYROID CANCER80 Aggressive Variants of Papillary Thyroid Carcinoma and Poorly Differentiated Carcinoma81 Miscellaneous and Unusual Tumors of the Thyroid Gland   82 Pathology of Miscellaneous and Unusual Tumors of the Thyroid GlandPART VII. UNDIFFERENTIATED TUMORS:  MEDULLARY THYROID CARCINOMA83 Clinical Aspects of Medullary Thyroid Carcinoma84 Cytology and Pathology of Medullary Carcinoma85 Medullary Carcinoma of the Thyroid: Surgical Management86 Radionuclide Imaging of Medullary Carcinoma87 PET/CT in Medullary Thyroid Cancer88 Radiation Therapy in Medullary Cancer89 Medullary Carcinoma of the Thyroid: Chemotherapy90 A Comparison of the ATA, NCCN, ETA, and BTA Guidelines for the Management of Medullary Thyroid CancerPART VIII. UNDIFFERENTIATED TUMORS:  THYROID LYMPHOMA91 Thyroid Lymphoma92 Pathology of Lymphoma of the Thyroid93 PET/CT in Lymphoma and Lymphoma of the ThyroidPART IX. UNDIFFERENTIATED TUMORS: ANAPLASTIC THYROID CANCER94 Anaplastic Thyroid Carcinoma: Clinical Aspects95 Surgical Management of Anaplastic Thyroid Carcinoma96  Pathology of Anaplastic Carcinoma97 PET/CT in Anaplastic Cancer of the Thyroid98 Anaplastic Thyroid Cancer99 Chemotherapy for Anaplastic Thyroid Cancer100 Anaplastic Thyroid Carcinoma:  Prognosis PART X. NEW FRONTIERS AND FUTURE DIRECTIONS101 Advances in Radiation Therapy102 New Approaches in Nuclear Medicine for Thyroid Cancer103 124I in Differentiated Thyroid Cancer104 Future Directions for Advanced Thyroid Cancer Therapy105 Potential Approaches to Chemotherapy of Thyroid Cancer in the FuturePART XI. Additional Resources106 Prophylaxis against Radiation Exposure from Radioiodine107 Low Iodine Diets  108 Appendix A: Books and Manuals109 Appendix B: Additional Sources of Information: Support groups, Websites and additional information110 Appendix C: Forms and Instructions for Patients Treated with Radioactivity

Erscheint lt. Verlag 19.9.2016
Zusatzinfo XXXI, 1049 p. 271 illus., 81 illus. in color.
Verlagsort New York
Sprache englisch
Original-Titel Thyroid Cancer
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Chirurgie
Medizinische Fachgebiete Innere Medizin Endokrinologie
Medizin / Pharmazie Medizinische Fachgebiete Onkologie
Medizinische Fachgebiete Radiologie / Bildgebende Verfahren Nuklearmedizin
Medizinische Fachgebiete Radiologie / Bildgebende Verfahren Radiologie
Schlagworte Cancer • Differentiated thyroid cancer • Radioiodine scintigraphy • Radionuclide imaging • SPECT-CT • stunning • Surgery • Thyroid
ISBN-10 1-4939-3314-0 / 1493933140
ISBN-13 978-1-4939-3314-3 / 9781493933143
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