Diabetes & C-Peptide (eBook)

Scientific and Clinical Aspects

Anders A.F. Sima (Herausgeber)

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2011 | 2012
XIII, 169 Seiten
Humana Press (Verlag)
978-1-61779-391-2 (ISBN)

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In Diabetes & C-Peptide: Scientific and Clinical Aspects, a renowned group of leading researchers and physicians offers a comprehensive overview of the role of C-Peptide in type 1 diabetes. The book is organized in five sections. An Introductory section provides the background and key features of C-peptide's physiological function and how its deficiency contributes to complications. The second section describes up-to-date information on the biochemical and molecular actions of C-peptide, including membrane binding, interactions with insulin as well as the interaction between C-peptide and zinc and effects on microvascular vasoreactivity. The third section summarizes in vivo animal studies of the type 1 diabetic complications. The fourth section reviews the clinical efforts of C-peptide on inflammation, cardiovascular complication, neuropathy and nephropathy. Finally, in the Conclusions section, a summary of the present state of C-peptide, outstanding questions, and the likely direction of the field are offered. Developed by the foremost investigators in the rapidly moving field of C-peptide research, Diabetes & C-Peptide: Scientific and Clinical Aspects is an important contribution to the literature for all researchers and physicians concerned about type 1 diabetes.


In Diabetes & C-Peptide: Scientific and Clinical Aspects, a renowned group of leading researchers and physicians offers a comprehensive overview of the role of C-Peptide in type 1 diabetes. The book is organized in five sections. An Introductory section provides the background and key features of C-peptide's physiological function and how its deficiency contributes to complications. The second section describes up-to-date information on the biochemical and molecular actions of C-peptide, including membrane binding, interactions with insulin as well as the interaction between C-peptide and zinc and effects on microvascular vasoreactivity. The third section summarizes in vivo animal studies of the type 1 diabetic complications. The fourth section reviews the clinical efforts of C-peptide on inflammation, cardiovascular complication, neuropathy and nephropathy. Finally, in the Conclusions section, a summary of the present state of C-peptide, outstanding questions, and the likely direction of the field are offered. Developed by the foremost investigators in the rapidly moving field of C-peptide research, Diabetes & C-Peptide: Scientific and Clinical Aspects is an important contribution to the literature for all researchers and physicians concerned about type 1 diabetes.

PrefaceForewordChapter 1: C-peptide and Insulin – A Happy Marriage  Donald. F. SteinerChapter 2: Peptide Interactions of Proinsulin C-peptideCharlotte Nerelius, Emma Lindahl, Michael Landreh and Hans JörnvallChapter 3: The Effect of Combined C-peptide and Zinc on Cellular FunctionDana M. SpenceChapter 4: C-Peptide Signaling in the Kidney and Protection from Diabetic Nephropathy  Nigel J. BrunskillChapter 5:  Role of C-Peptide in the Regulation of Microvascular Blood Flow Thomas Forst, Matthias M. Weber, Thomas Kunt, Andreas Pfützner Chapter 6: Is NO-eNOS a target for C-peptide action and its protective effects on diabetic nephropathy?  Kazuhiro Kimura and Akihiro KamikawaChapter 7: Renoprotective Effects of C-Peptide in Type I DiabetesLina Nordquist, Ǻsa Kallas, Sara Stridh, Fredrik Palm, John Wahren   Chapter 8: The Mechanisms Underlying the Effects of C-peptide on Type I Diabetic NeuropathyHideki Kamiya, Wei-Xian Zhang, Anders A.F. SimaChapter 9: C-peptide and Type 1 Diabetic EncephalopathyAnders A.F. Sima, Wei-Xian ZhangChapter 10: C-peptide: a New Molecule with Anti-Inflammatory PropertiesJaime Haidet, Vincenza Cifarelli, Xuehui Geng, Massimo Trucco, Patrizia LuppiChapter 11: C-peptide: Connecting Diabetes with Macrovascular Complications Karen E. Porter, Romana S. MughalChapter 12: C-peptide and Diabetic Neuropathy in Patients with Type I DiabetesKarin Ekberg, John WahrenChapter 13: Proatherogenic Effects of C-PeptideDaniel Walcher, Nikolaus MarxChapter 14: Conclusions and Future Outlook  Anders A.F. Sima

Erscheint lt. Verlag 4.11.2011
Reihe/Serie Contemporary Diabetes
Zusatzinfo XIII, 169 p. 63 illus., 35 illus. in color.
Verlagsort Totowa
Sprache englisch
Themenwelt Medizinische Fachgebiete Innere Medizin Diabetologie
Medizinische Fachgebiete Innere Medizin Endokrinologie
Schlagworte Diabetes
ISBN-10 1-61779-391-4 / 1617793914
ISBN-13 978-1-61779-391-2 / 9781617793912
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