Bioinformatics in Human Health and Heredity

book “Ancient Inhabitants of Jebel Moya” published by the Cambridge Press under the joint authorship of Rao and two anthropologists. On the basis of work done at CU during the two year period, 1946-1948, Rao earned a Ph.D. degree and a few years later Sc.D. degree of CU and the rare honor of life fellowship of Kings College, Cambridge. He retired from ISI in 1980 at the mandatory age of 60 after working for 40 years during which period he developed ISI as an international center for statistical education and research. He also took an active part in establishing state statistical bureaus to collect local statistics and transmitting them to Central Statistical Organization in New Delhi. Rao played a pivitol role in launching undergraduate and postgraduate courses at ISI. He is the author of 475 research publications and several breakthrough papers contributing to statistical theory and methodology for applications to problems in all areas of human endeavor. There are a number of classical statistical terms named after him, the most popular of which are Cramer-Rao inequality, Rao-Blackwellization, Rao’s Orthogonal arrays used in quality control, Rao’s score test, Rao’s Quadratic Entropy used in ecological work, Rao’s metric and distance which are incorporated in most statistical books. He is the author of 10 books, of which two important books are, Linear Statistical Inference which is translated into German, Russian, Czec, Polish and Japanese languages,and Statistics and Truth which is translated into, French, German, Japanese, Mainland Chinese, Taiwan Chinese, Turkish and Korean languages. He directed the research work of 50 students for the Ph.D. degrees who in turn produced 500 Ph.D.’s. Rao received 38 hon. Doctorate degree from universities in 19 countries spanning 6 continents. He received the highest awards in statistics in USA,UK and India: National Medal of Science awarded by the president of USA, Indian National Medal of Science awarded by the Prime Minister of India and the Guy Medal in Gold awarded by the Royal Statistical Society, UK. Rao was a recipient of the first batch of Bhatnagar awards in 1959 for mathematical sciences and and numerous medals in India and abroad from Science Academies. He is a Fellow of Royal Society (FRS),UK, and member of National Academy of Sciences, USA, Lithuania and Europe. In his honor a research Institute named as CRRAO ADVANCED INSTITUTE OF MATHEMATICS, STATISTICS AND COMPUTER SCIENCE was established in the campus of Hyderabad University. Pranab K. Sen is Cary C. Boshamer Professor of Biostatistics and Statistics at the University of North Carolina, and is a Fellow of the Institute of Mathematical Statistics and of the American Statistical Association. He is also an elected member of the International Statistical Institute.Prenab K. Sen is author or co-author of multiple volumes in Mathematical Statistics, Probability Theory and Biostatistics, and has published extensively in nonparametrics, multivariate and sequential analysis, and reliability and survival analysis.

Chapter 1: Introduction: Wither Bioinformatics in Human Health and Heredity Section A: Microarray Analysis Chapter 2: Hierarchical Bayesian Methods for Microarray Data Chapter 3: Statistical Analysis of Time-Course and Dose-Response Microarray Experiments Chapter 4: Meta-analysis of High Throughput Oncology Data Section B: Analytical Methods Chapter 5: A Statistical Appraisal of Biomarker Selection Methods Applicable to HIV/AIDS Research Chapter 6: The use of Hamming Distance in Bioinformatics Chapter 7: Asymptotic Expansion of the Distributions of the Least Squares Estimators in Factor Analysis and Structural Equation Modeling Chapter 8: Multiple Testing and False Discovery Rate Issues in Bioinformatics Section C: Genetics and DNA Forensics Chapter 9: Applications of Bayesian Neural Networks in Prostate Cancer Study Chapter 10: Statistical Methods for Detecting Functional Divergence of Gene Families Chapter 11: Sequence Pattern Discovery with Applications to Understanding Gene Regulation and Vaccine Design Chapter 12: Single-locus Association Tests by Ordered Statistics Chapter 13: A Molecular Information Method to Estimate Population Admixture Chapter 14: Effects of Inclusion of Relatives in DNA Databases: Empirical Observations from 13K SNPs in Hap-Map Population Data Section D: Epidemiology Chapter 15: Measurement and Analysis of Quality of Life in Epidemiology Chapter 16: Quality of Life Perspectives in Chronic Disease and Disorder Studies Chapter 17: Bioinformatics of Obesity Chapter 18: Exploring Genetic Epidemiology Data with Bayesian Networks Section E: Database Issues Chapter 19: Perturbation Methods for Protecting Numerical Data: Evolution and Evaluation Chapter 20: Protecting Data Confidentiality in Public Release Datasets: Approaches Based on Multiple Imputation