Phytochemistry, the Military and Health

A member of the American Chemical Society (ACS), the Phytochemistry Society of Europe (PSE), the National Organization for the Professional Advancement of Black Chemists and Chemical Engineers (NOBCChE), and an Associate Member of the Royal Society of Chemistry (RSC), Andrew is a Medicinal Chemist trained under the Wellcome Center for Anti-infectives Research (WCAiR) at the Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee in Scotland as part of his PhD studies. He also did his PhD at the Mbarara University of Science and Technology under the Pharm-Biotechnology and Traditional Medicine Centre in Uganda and attended a Phytochemistry PhD summer School at Kenya’s Egerton University on a DAAD scholarship. His main area of interest is drug design and development using medicinal chemistry aspects and various computational and synthetic techniques to obtain logical hits to leads for particular biological targets from synthetic scaffolds in various libraries, de novo as well as from natural products. He did his MSc degree in Applied Chemistry (Natural Product Chemistry). He has a passion to coach and train upcoming drug discoverers to search for drugs beyond plant extracts to compound level towards optimization. Before joining the academia, Andrew served in various portfolios including but not limited to being Quality Assurance Manager for Valid Nutrition’s therapeutic foods’ factory, assistant Quality Manager (Shifts controller) for Alliance one international tobacco processors and graduate trainee for the Japanese Tobacco International (JTI), Malawi factory. He founded Leptons Scientific consultants in 2011 and has provided consultancy services in his areas of expertise to various clients. For close to a decade now, Andrew has also been researching military strategies, security and weaponry among others. He studied intelligence analysis and is trained in H2H close combat. He has published various journal articles and book chapters with various publishers such as Elsevier and is a reviewer for various journals including Systematic Reviews, Tuberculosis and of late, the African Health Sciences among others. Apart from this book, he is also the lead editor of the book ‘Poisonous Plants and Phytochemicals in Drug Discovery’ by Wiley. Currently, Andrew is a Chemistry lecturer at the Malawi University of Science and Technology in Malawi. Chukwuebuka Egbuna (PhD) is a chartered chemist and academic researcher. He is a member of the Institute of Chartered Chemists of Nigeria (ICCON), the Nigerian Society of Biochemistry and Molecular Biology (NSBMB), and the Royal Society of Chemistry (RSC) (United Kingdom). Dr. Egbuna is the founder and editor of the Elsevier book series on Drug Discovery Update. The series includes books, monographs, and edited collections from all areas of drug discovery including emerging therapeutic claims for the treatment of diseases. He has published research articles in many international journals of repute and is ranked among the top 500 Nigerian scientists in SciVal/SCOPUS. He has edited more than 25 books with Elsevier, Springer, Wiley, and Taylor & Francis. His most recent book is the three volume Coronavirus Drug Discovery, published by Elsevier. Dr. Egbuna is the founder and the publishing director of IPS Intelligentsia Publishing Services.

1. Introduction to phytochemicals and the military

Part A: Uses and historical perspectives of plants and their chemicals 2. Historical use of plants in warfare 3. Importance of forests to the military beyond physical training 4. Phytochemicals used in body agility and remediation from tissue mutilation 5. Important histaminic and antihistaminic plants and their potential role in military operations 6. Plants as warfare strategic tools 7. Phyto-therapy against conflict related trauma 8. Important plants in emergency military surgical procedures 9. Potential wartime phyto-sedatives for the field 10. Useful plants and phytochemicals for wound healing and physical fitness 11. Emergency phytomedicine during armed conflicts

Part B: Plants and phytochemicals used as therapeutics 12. War and conventional plant-based drug development 13. Development of phyto-antidotes against chemical agents 14. Molecular optimization of phytochemicals into weapons and antidotes

Part C: The good and adverse sides of phytocompounds 15. Important military amphibious phytotoxins 16. Classes of phytochemical weapons 17. Phytochemical based nano-particles as military foes and friends 18. Nanotechnology-targeted herbal drug delivery as fast and efficient antidotes against systemic poisons 19. Terrorism, counter-terrorism and phytochemicals

Part D: Mechanistic approach to phyto-chemical weapons 20. Chemical and pharmacological mechanisms of nerve agent poisoning 21. Mechanisms of phytochemicals as antidotes to chemical weapons 22. Application of metabolomics in emergency phytochemical poisoning and remediation

Part E: Management, protocols, regulation and future perspectives of phytochemicals 23. Laboratory protocols on handling phytochemical warfare agents 24. Detection and identification of phytochemical weapons 25. Management and regulation of potential weaponizable plants 26. All-plant emergency first aid kits innovations 27. The future of phytochemicals in the military 28. Conclusions