New Developments in Tissue Engineering and Regeneration (eBook)

Preface 6
Contents 7
Computational Modelling of Wound Healing Insights to Develop New Treatments 8
1 Introduction 9
2 Healthy Skin 10
3 Wound Healing 12
4 Severe Wound Treatments 14
5 Computational Models of Wound Healing 16
6 Discussion and Conclusions 21
References 23
Traction Force Microscopy in Differentiating Cells 27
1 Introduction 27
2 Cell Cytoskeleton and Force Generation 28
3 Cell Traction Force Measurements 28
3.1 Cell Traction Force Microscopy and Analysis 30
4 Mechanical Properties of Mesenchymal and Committed Cells 32
4.1 Traction Forces Exerted by Differentiating Adipocytes 33
5 Summary 35
References 35
Adaptive Multi-resolution Volumetric Modeling of Bone Micro-structure 37
1 Introduction 38
2 Approach 39
3 Implementation 40
4 Examples and Discussion 42
4.1 2D Examples—Adaptive Models 42
4.2 3D Examples—Bone Fragment Extraction 44
4.3 3D Examples—Multi-resolution Models 45
4.4 3D Examples—Curvature Analysis 45
4.5 Topological Preservation 47
4.6 3D Examples—Adaptive Models 52
5 Summary and Conclusions 54
References 55
Low Temperature 3D Printing of Drug Loaded Bioceramic Scaffolds and Implants 57
1 Introduction 57
2 3D Printing Technology 58
3 Material Approaches to 3D Powder Printing of Ceramic Bone Scaffolds 61
4 Drug Modification of 3D Printed Implants 63
5 Conclusion 66
References 68
A Biomechanical Approach for Bone Regeneration Inside Scaffolds Embedded with BMP-2 73
1 Introduction 73
2 Materials and Methods 74
2.1 Degradation Model 75
2.2 Bone Tissue Regeneration Model 76
2.3 Material Properties by Homogenization 78
3 Results 79
3.1 Results for Scaffolds Without BMP-2 79
3.2 BMP-2 Embedded Scaffolds. Comparison with Experimental Data 80
3.3 Results for Periodic Porous Scaffolds Embedded with BMP-2 80
4 Discussion 84
Appendix 87
References 91