Enantiocontrolled Synthesis of Fluoro-Organic Compounds
John Wiley & Sons Inc (Verlag)
978-0-471-97372-0 (ISBN)
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Written by a leading expert in the field, this is a comprehensivereview of the methods for preparing stereochemically definedfluorine-containing compounds of biomedical importance.
Fluorinated organic compounds are well known for their unusualreactivity but the growing importance of these compounds in thebiomedical field has been accompanied by an increasing awareness ofthe necessity to synthesise and explore the biological propertiesof stereochemically defined fluoro-compounds. This is the firstbook written on this exciting area of research.
It contains:
* detailed reviews on stereocontrolled synthesis of biologicallyimportant compounds
* 21 chapters covering the main areas of asymmetric synthesis andbiocatalysts where fluorine plays a key role
* mechanisms and methods for synthesizing fluoro-organiccompounds
Written for professionals involved in organic, physical andorganofluorine chemistry, natural product synthesis, biological,pharmaceutical and other life science related industries.
Vadim A. Soloshonok is the editor of Enantiocontrolled Synthesis of Fluoro-Organic Compounds: Stereochemical Challenges and Biomedical Targets, published by Wiley.
1. Asymmetric Fluorination
2. Asymmetric of Fluoroalkylation
3. Synthesis of Stereochemically Defined Fluoro-Organic Compoundsvi Dehydroxy-Fluorination and Related Reactions
4. Asymmetric Synthesis of Fluoro-Organic Compounds via ChiralSulfoxide Chemistry
5. Synthesis of Stereochemically Defined Trifluoromethyl-ContainingCompounds from (S)-3,3,3-Trifluoropropene Oxide
6. Asymmetric Reduction of Fluorine-Containing CarbonylCompounds
7. Asymmetric Aldol Reactions of Fluoro-Carbonyl Compounds
8. Asymmetric Michael Addition of Reactions of Fluorocarbons
9. Asymmetric Oxidation of Fluoro-Olefins
10. Biocatalytic Approach to Enantiomerically EnrichedFluoro-Organic Compounds
11. Stereocontrolled Syntheses of Fluorinated Carbohydrates
12. Asymmetric Synthesis of Fluoro-amino acids
13. Chiral non-racemic Fluorinated Nucleosides -
Recent Synthetic Methods
14. Asymmetric Syntheses and Resolutions of Fluorinated VolatileAnesthetics
15. Fluorine-Containing Chiral Auxiliaries and Ligands for GeneralAsymmetric Synthesis
16. Fluorine-Containing Agents for Determining Enantiomeric Excessof Chiral Molecules
17. Fluorine-Containing Chiral Liquid Crystals: Syntheses andProperties
18. Synthesis of Enantiopure alpha-Trifluoromethyl Alcohols viaChiral Lewis Acid-Catalyzed Carbonyl-Ene Reactions and theirApplication in the Design of New Liquid Crystals
19. Coordination Ability of Fluorine to Proton or Metals Based onExperimental and Theoretical Evidence
20. Physical and Structural Size of Fluorine in Fluoro-OrganicCompounds
21. The Chemical and Physiological Size of Fluorine
| Erscheint lt. Verlag | 9.7.1999 |
|---|---|
| Verlagsort | New York |
| Sprache | englisch |
| Maße | 163 x 237 mm |
| Gewicht | 1106 g |
| Themenwelt | Naturwissenschaften ► Chemie ► Anorganische Chemie |
| Naturwissenschaften ► Chemie ► Organische Chemie | |
| Technik ► Umwelttechnik / Biotechnologie | |
| ISBN-10 | 0-471-97372-6 / 0471973726 |
| ISBN-13 | 978-0-471-97372-0 / 9780471973720 |
| Zustand | Neuware |
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