Bioceramic Coatings for Medical Implants (eBook)

Robert B. Heimann is Professor (em.) of Applied Mineralogy and Materials Science, formerly at Technische Universität Bergakademie Freiberg, Germany. He received his scientific degrees from Freie Universität (FU) Berlin, Germany, and served as a research fellow at FU Berlin and the Karlsruhe Institute of Technology. In 1979, he moved to Canada and worked as a research associate at the McMaster University, was visiting professor at the University of Toronto, and held various positions as senior researcher and manager in industry and government institutions. In 1993, he became Full Professor in Freiberg. Until his retirement in 2004, Professor Heimann has authored over 280 scientific publications including several books, was board member and chair of several scientific committees, and vice president and then president of the International Council for Applied Mineralogy (ICAM). In 2001, he was honored with the Georg-Agricola-Medal of the German Mineralogical Society (DMG). Hans D. Lehmann is an organic chemist with an extensive working experience in polymer chemistry and polymer processing technology. He received his Diploma in chemistry from the Martin Luther University Halle-Wittenberg, Germany, in 1962. He worked as a polymer chemist and team leader in production-related research at the chemical company VEB BUNA (now Dow Chemical and Styron Deutschland, respectively). He specialized in the development of polymerization catalysts, modeling of monomer and polymer syntheses as well as their processing technologies and analytics. Moreover, until Germany?s reunification Hans Dieter Lehmann was responsible for the coordination between academia, industry and government. Since 1994 he worked as a consultant for patent law and process concepts, and co-authored several patents related to structural and functional surface coatings

PREFACE
BIOMATERIALS - A HISTORICAL PERSPECTIVE
THE NATURE OF BIOCERAMIC MATERIALS
SCOPE AND SOCIOECONOMIC ASPECTS OF BIOCERAMICS
Europe
USA and Canada
Asia
PRINCIPLES OF BIOCOMPATIBILITY
Bioinert Ceramics
Biotolerant Ceramics
Bioactive Ceramics
Osseoconduction vs. Osseoinduction
HIERARCHICAL STRUCTURE OF BONE TISSUE
FUNDAMENTALS OF INTERACTION OF BIOCERAMICS AND LIVING MATTER
Tissue Level
Cellular Level
STRUCTURE AND PROPERTIES OF SELECTED BIOCERAMICS
Bioinert Ceramics: Alumina, Zirconia, Titania, and Others
Bio(osseo)conductive Ceramics: Bioglasses, Hydroxyapatite, Tricalcium Phosphates, Tetracalcium Phosphate, Transition-Metal Substituted Calcium Orthophosphates, Resorbable Calcium Phosphates, Composite Materials, and Others
TECHNOLOGY OF COATING DEPOSITION
Biomimetic Route
Sol-Gel Deposition
Dip Coating
Electrochemical Deposition
Electrophoretic Deposition
Chemical Vapor Deposition (CVD)
Ion Implantation
Magnetron Sputtering
Plasma Electrolytic Oxidation (PEO)
Micro-Arc Oxidation (MAO)
Laser Cladding
Thermal Spraying (APS, HVOF, PLD, etc.)
Suspension Plasma Spraying (SPS)
Cold Gas Dynamic Spraying (CGDS)
Others
STRUCUTRE, PROPERTIES, AND BIOLOGICAL FUNCTION OF BIOCERAMIC COATINGS
In Vitro Behavior
In Vivo Behavior
IN VITRO TESTING BIOMINERALIZATION PROPERTIES OF BIOCERAMIC COATINGS
Composition of Solutions Mimicking Human ECF (Extracellular Fluid)
Biomineralization by Immersion in ECF-Simulating Solutions
Cell Proliferation, Spreading, Vitality and Differentiation Studies
ISO-10993 Standard Testing
Alkaline Phosphatase (ALP) Assay Using ELISA
Osteocalcin Secretion
Osteopontin and Osteonectin Assays
Others
CHEMICAL AND BIOLOGICAL FUNCTIONALIZATION OF BIOCERAMIC COATINGS
FUTURE DEVELOPMENT AND OUTLOOK
Preface
Biomaterials - A Historical Perspective
Socio-economic Aspects and Scope of Bioceramic Materials and Biomedical Implants
Fundamentals of Interaction of Bioceramics and Living Matter
Structure and Properties of Bioceramics used in Orthopaedic and Dental Implants
Technology of Coating Deposition
Deposition, Structure, Properties, and Biological Function of Plasma-Sprayed Bioceramic Coatings
Characterization and Testing of Bioceramic Coatings
Future Developments and Outlook