Protein and Peptide Folding, Misfolding, and Non-Folding (eBook)

Reinhard Schweitzer-Stenner, PhD, is Professor and currently the Head of the Chemistry Department at Drexel University. Dr. Schweitzer-Stenner also heads the biospectroscopy research group. His research investigates peptide structure and functionally relevant heme distortions as well as ligand-receptor binding on the surface of mast cells. With more than 150 published research articles, Dr. Schweitzer-Stenner is widely recognized as a leader and pioneer in the study of the conformational properties of unfolded peptides.

A. Introduction

1. Why are we interested in the unfolded peptides and proteins?
Vladimir Uversky and Keith Dunker

B. Conformational analysis of unfolded states

2. Exploring the landscape of small peptides with MD simulations
Gerhard Stock, Abhinav Jain, Laura Riccardi, and Phuong H. Nguyen

3. Local backbone preferences and nearest neighbor effects in the unfolded and native states
Joe DeBartolo, Abhishek Jha, Karl F. Freed, and Tobin R. Sosnick

4. Short-distance FRET applied to the polypeptide chain
Maik Jacob and Werner Nau

5. Solvation and electrostatics as determinants of conformational propensities in unfolded peptides and proteins
Franc Avbelji

6. Experimental and Computational Studies of Polyproline II Propensity
W. Austin Elam, Travis P. Schrank, Vincent J. Hilser

7. Mapping conformational dynamics in unfolded polypeptide chains using short model peptides by NMR spectroscopy
Daniel Mathieu, Karin Rybka, Jürgen Graf and Harald Schwalbe

8. Secondary Structure and Dynamics of a Family of Disordered Proteins
Pranesh Narayanaswami and Gary Daughdrill

C. Disordered Peptides and Molecular Recognition

9. Binding promiscuity of unfolded peptides
Christopher J. Oldfield, Bin Xue, A. Keith Dunker, and Vladimir N. Uversky

10. Intrinsic flexibility of nucleic acid chaperone proteins from pathogenic RNA viruses
Roland Ivanyi-Nagy, Zuzanna Makowska, and Jean-Luc Darlix

D. Aggregation of disordered peptides

11. Self-Assembling Alanine-Rich Peptides of Biomedical and Biotechnological Relevance
Thomas Measey and Reinhard Schweitzer-Stenner

12. Structural Elements Regulating Interactions in the Early Stages of Fibrillogenesis: A Human Calcitonin Model System
Rosa Maria Vitale, Giuseppina Andreotti, Pietro Amodeo, and Andrea Motta

13. Solution NMR Studies of Abeta Monomers and Oligomers
Chunyu Wang

14. Thermodynamic and Kinetic Models for Aggregation of Intrinsically Disordered Proteins
Scott L. Crick and Rohit V. Pappu

15. Modifiers of protein aggregation - from non-specific to specific interactions
Michal Levy-Sakin, Roni Scherzer-Attali and Ehud Gazit

16. Computational Studies of Folding and Assembly of Amyloidogenic Proteins
J. Srinivasa Rao, Brigita Urbanc and Louis Cruz