Hybrid Imaging in Cardiovascular Medicine

Yi-Hwa Liu, Ph.D. is Senior Research Scientist in Cardiovascular Medicine at Yale University School of Medicine and Technical Director of Nuclear Cardiology at Yale New Haven Hospital, New Haven, CT. He is Associate Professor (Adjunct) of Biomedical Imaging and Radiological Sciences at National Yang-Ming University, Taipei, Taiwan, and Professor (Adjunct) of Biomedical Engineering at Chung Yuan Christian University, Taoyuan, Taiwan. He is an elected senior member of Institute of Electrical and Electronic Engineers (IEEE) and a full member of Sigma Xi of The Scientific Research Society of North America. He has served for many a years on the Editorial Boards of the World Journal of Cardiology, Journal of Clinical and Experimental Cardiology, American Journal of Nuclear Medicine and Molecular Imaging, Current Molecular Imaging Journal, and American Journal of Nuclear Medicine and Molecular Imaging. He has also served as National Member of American Heart Association (AHA) grants review Committee since 2004, and as Associate Editor of Medical Physics since 2009. Dr. Liu received his BS degree of Biomedical Engineering at Chung Yuan Christian University, Taoyuan, Taiwan, MS degree of Electrical and Computer Engineering at University of Missouri, Columbia, MO, and PhD degree of Electrical and Computer Engineering at Rensselaer Polytechnic Institute, Troy, NY. He completed post-doc trainings in electrophysiology and cardiovascular physiology at Georgetown University School of Medicine and in nuclear cardiology at Yale University School of Medicine. He joined the faculty at Yale University School of Medicine as Assistant Professor (1998 – 2004) and Associate Professor of Medicine (2004 – 2014). His primary research involves non-coherent image restoration, nuclear cardiac image reconstruction and quantification. He is one of the pioneers in the fields of fluorescence microscopic image restoration and nuclear cardiac image reconstruction and quantification. He is the author of over 50 peered review publications, the leading editor of a book entitled "Cardiovascular Imaging" (CRC Press, Taylor & Francis Group, London, UK) and Co-inventor of the Wackers-Liu CQ™ SPECT Quantification Method, FDA-approved Commercial Software Package. Albert J. Sinusas, M.D., FACC, FAHA is Professor of Medicine (Section of Cardiovascular Medicine) and Radiology and Biomedical Imaging, at Yale University School of Medicine, and Director of the Yale Translational Research Imaging Center (Y-TRIC), and Director of Advanced Cardiovascular Imaging at Yale New Haven Hospital. He received a BS degree at Rensselaer Polytechnic Institute, MD degree at University of Vermont, College of Medicine, and completed training in internal medicine at the University of Oklahoma, and training in cardiology and nuclear cardiology at the University of Virginia. He joined the faculty at Yale University School of Medicine in 1990 where he has remained. Dr. Sinusas has served as a standing member of the Clinical and Integrated Cardiovascular Sciences (CICS) and Medical Imaging (MEDI) study sections of the National Institutes of Health. Dr. Sinusas has been a member of the Board of Directors of the Cardiovascular Council (CVC) of the Society of Nuclear Medicine (SNM), and the SNM Molecular Imaging Center of Excellence (MICoE), and the American Society of Nuclear Cardiology. He was the 2008 recipient of the SNM Hermann Blumgart Award. His research is directed at development, validation and application of non-invasive cardiovascular imaging approaches for the assessment of cardiovascular pathophysiology, including the targeted molecular assessment of myocardial ischemic injury, angiogenesis, arteriogenesis, and post–infarction atrial and ventricular remodeling. The investigation of these biological processes involves, ex vivo and in vivo imaging in animal models of cardiovascular disease and humans. This translational research employs the 3–D modalities of X-ray computed tomography (CT) and fluoroscopy, SPECT/CT, PET/CT, echocardiography, and MR imaging in an animal physiology laboratory and clinical environment. Dr. Sinusas has been the principal investigator of several NIH grants involving multi-modality cardiovascular imaging, and directs a NIH funded T32 grant providing training in multi-modality molecular and translational cardiovascular imaging. He is the author of over 200 peer reviewed publications and invited reviews related to cardiovascular imaging, and co-edited a textbook on Cardiovascular Molecular Imaging published in 2007. 　

PRINCIPLES, INSTRUMENTATION, TECHNIQUES, APPLICATIONS AND CASE ILLUSTRATIONS OF HYBRID IMAGING. Principles and Instrumentation of SPECT/CT. Cardiovascular PET/CT. Development of a Second Generation Whole Body Small Animal SPECT/MR Imaging System. Integrated PET and MRI of the Heart. CT-MRI. Hybrid X-Ray Luminescence and Optical Imaging. X-ray Fluoroscopy – Echocardiography. Combined Ultrasound and Photoacoustic Imaging. Hybrid Intravascular Imaging in the Study of Atherosclerosis. MULTIMODALITY PROBES FOR HYBRID IMAGING. Preclinical Evaluation of Multimodality Probes. Multimodality Probes for Cardiovascular Imaging. QUANTITATIVE ANALYSES AND CASE ILLUSTRATIONS OF HYBRID IMAGING. Recent Developments and Applications of Hybrid Imaging Techniques. Multimodality Image Fusion. Quantitative Cardiac SPECT/CT. Evaluations of Cardiovascular Diseases with Hybrid PET-CT Imaging. Quantitative Analyses and Case Studies of Hybrid PET-MRI Imaging. Merging Optical with Other Imaging Approaches. FUTURE CHALLENGES OF HYBRID IMAGING TECHNIQUES. Hybrid Instrumentation versus Image Fusion: Path to Multibrid Visualization. Concerns with Radiation Safety.