Chemometric Methods in Capillary Electrophoresis (eBook)

Grady Hanrahan, PhD, received his doctorate in environmental analytical chemistry from the University of Plymouth, England. Dr. Hanrahan is currently the John Stauffer Endowed Professor of Analytical Chemistry at California Lutheran University with research interests in the use of modern chemometric methods in the design and development of environmental and bioanalytical instrumentation. He is also exploring the use of neural and evolutionary computational techniques for solving complex chemical problems. Frank A. Gomez, PhD, received his BS in chemistry from California State University, Los Angeles (CSULA), and his PhD in chemistry from UCLA, where he was a NIH Predoctoral Fellow. From 1991-1994, he was a Damon Runyon-Walter Winchell Cancer Research Fund Postdoctoral Fellow in the department of chemistry at Harvard University. He is a professor of chemistry at CSULA and is a visiting associate at Caltech in the Applied Physics department.

PREFACE.

ACKNOWLEDGMENTS.

EDITOR BIOGRAPHIES.

CONTRIBUTORS.

KEY ACRONYMS.

I EXPERIMENTAL DESIGN AND OPTIMIZATION CONSIDERATIONS.

1 INTRODUCTION (Grady Hanrahan and Frank A. Gomez).

2 EXPERIMENTAL DESIGN IN METHOD OPTIMIZATION AND ROBUSTNESS
TESTING (Bieke Dejaegher, Alexandra Durand, and Yvan Vander
Heyden).

3 CHEMOMETRICAL EXPERIMENTAL DESIGN-BASED OPTIMIZATION STUDIES
IN CAPILLARY ELECTROPHORESIS APPLICATIONS (Ruthy Montes, Toni
Ann Riveros, Froseen Dahdouh, Grady Hanrahan, and Frank A.
Gomez).

4 APPLICATION OF CHEMOMETRIC METHODS IN DRUG PURITY
DETERMINATION BY CAPILLARY ELECTROPHORESIS (Gerhard K.E.
Scriba).

5 OPTIMIZATION OF MICELLAR ELECTROKINETIC CHROMATOGRAPHY
SEPARATION CONDITIONS BY CHEMOMETRIC METHODS (Jessica L.
Felhofer and Carlos D. Garcia).

6 CHEMOMETRIC METHODS FOR THE OPTIMIZATION OF CE AND CE-MS
IN PHARMACEUTICAL, ENVIRONMENTAL, AND FOOD ANALYSIS (Javier
Hernández-Borges, Miguel Ángel Rodríguez-Delgado,
and Alejandro Cifuentes).

7 OPTIMIZATION OF THE SEPARATION OF AMINO ACIDS BY CAPILLARY
ELECTROPHORESIS USING ARTIFICIAL NEURAL NETWORKS (Amanda Van
Gramberg, Alison Beavis Lucas Blanes, and Philip Doble).

II EXPLORATORY DATA ANALYSIS, PREDICTION, AND
CLASSIFICATION.

8 DEVELOPMENT OF CAPILLARY ELECTROPHORESIS FINGERPRINTS AND
MULTIVARIATE STATISTICS FOR THE DIFFERENTIATION OF OPIUM AND POPPY
STRAW SAMPLES (Raymond G. Reid, Susanne P. Boyle, Ann S. Low,
and David G. Durham).

9 MULTIVARIATE CURVE RESOLUTION BASED ON ALTERNATING LEAST
SQUARES IN CAPILLARY ELECTROPHORESIS (Javier Saurina).

10 APPLICATION OF CHEMOMETRICS IN CAPILLARY ELECTROPHORESIS
ANALYSIS OF HERBAL MEDICINES (Shao-Ping Li, Xiao-Jia Chen, and
Feng-Qing Yang).

11 CLINICAL PATTERN RECOGNITION ANALYSIS APPLYING ARTIFICIAL
NEURAL NETWORKS BASED ON PRINCIPAL COMPONENT ANALYSIS INPUT
SELECTION (Yaxiong Zhang and Hua Li).

12 CHEMOMETRIC METHODS APPLIED TO GENETIC ANALYSES BY CAPILLARY
ELECTROPHORESIS AND ELECTROPHORESIS MICROCHIP TECHNOLOGIES
(Maribel Elizabeth Funes-Huacca, Juliana Vieira Alberice, Lucas
Blanes, and Emanuel Carrilho).

13 EXPLORATORY DATA ANALYSIS AND CLASSIFICATION OF CAPILLARY
ELECTROPHORETIC DATA (Melanie Dumarey, Bieke Dejaegher,
Alexandra Durand, and Yvan Vander Heyden).

III QUANTITATIVE STRUCTURE RELATIONSHIPS.

14 CHEMOMETRICAL MODELING OF ELECTROPHORETIC MOBILITIES IN
CAPILLARY ELECTROPHORESIS (Mehdi Jalali-Heravi).

15 ASSESSMENT OF SOLUTE-MICELLE INTERACTIONS IN
ELECTROKINETIC CHROMATOGRAPHY USING QUANTITATIVE
STRUCTURE-RETENTION RELATIONSHIPS (Edgar P. Moraes,
Fernando G. Tonin, Luís G. Dias, João P.S. Farah, and
Marina F.M. Tavares).

16 CHEMOMETRICAL ANALYSIS OF CHEESE PROTEOLYSIS PROFILES BY
CAPILLARY ELECTROPHORESIS: PREDICTION OF RIPENING TIMES
(Natividad Ortega, Silvia M. Albillos, and María D.
Busto).

IV TRANSFORMATION TECHNIQUES.

17 TRANSFORMATION TECHNIQUES FOR CAPILLARY AND MICROCHIP
ELECTROPHORESIS (Takashi Kaneta).

INDEX.

"This book can be used as an initial desktop reference for
chemometric applications for CE but readers interested in more
in-depth applications of such techniques will need other
chemometrics textbooks . . . The concise presentation of the
chemometric methods and their application to CE-relevant data makes
the content with this book quite accessible to the novice and
provides a valuable data analysis resource for the practicing CE
analyst." (Anal Bioanal Chem, 2010)