Advances in Enzymology and Related Areas of Molecular Biology, Volume 78 (eBook)

Eric J. Toone, PhD, is Professor of Chemistry and Professor of Biochemistry at Duke University. He holds numerous patents and has written extensively on physical organic and biophysical chemistry. Professor Toone has served as a member of the Bioorganic and Natural Products Study Section at the National Institutes of Health, and is currently a member of the NSERC Organic & Inorganic Review panel (Canada). Professor Toone is the Deputy Director for the Advanced Research Projects Agency--Energy (ARPA-E) of the Department of Energy and directs ARPA-E's electrofuels program.

Contributors vii

Preface ix

Structure and Regulation of Type 2 Transglutaminase in Relation
to Its Physiological Functions and Pathological Roles 1

Carlo M. Bergamini, Russell J. Collighan, Zhuo Wang, and Martin
Griffin

Physiopathological Roles of Human Transglutaminase 2 47

Vittorio Gentile

Transglutaminase in Epidermis and Neurological Disease or What
Makes a Good Cross-Linking Substrate 97

Guylaine Hoffner, Amandine VanHoutteghem, William Andre, and
Philippe Djian

Transglutaminase 2: A New Paradigm for NF-B Involvement in
Disease 161

Soo-Youl Kim

Transglutaminase 2 At the Crossroads between Cell Death and
Survival 197

Mauro Piacentini, Manuela D'Eletto, Laura Falasca, Maria
Grazia Farrace, and Carlo Rodolfo

Tissue Transglutaminase and Its Role in Human Cancer Progression
247

Bo Li, Richard A. Cerione, and Marc Antonyak

Transglutaminase 2 Dysfunctions in the Development of Autoimmune
Disorders: Celiac Disease and TG2-/-Mouse 295

Zsuzsa Szondy, Ilma Korponay-Szabo, Robert Kiraly, and Laszlo
Fesus

Effects and Analysis of Transglutamination on Protein
Aggregation and Clearance in Neurodegenerative
Diseases 347

Zoltan Nemes

Transglutaminase-Mediated Remodeling of the Human Erythrocyte
Membrane Skeleton: Relevance for Erythrocyte Diseases with
Shortened Cell Lifespan 385

Laszlo Lorand, S. N. Prasanna Murthy, Anwar A. Khan, Weihua XUE,
Oksana Lockridge, and Athar H. Chishti

Irreversible Inhibitors of Tissue
Transglutaminase 415

Jeffrey W. Keillor, Nicolas Chabot, Isabelle Roy, Amina Mulani,
Olivier Leogane, and Christophe Pardin

Methionine Adenosyltransferase (S-Adenosylmethionine
Synthetase) 449

Maria A. Pajares and George D. Markham

Index 523