Scalable Green Chemistry

Stefan Koenig received his PhD from Yale University before conducting postdoctoral research at the ETH (Swiss Federal Institute) in Zurich, Switzerland. He embarked on his professional career in the pharmaceutical industry at Sepracor (now Sunovion Pharmaceuticals). Currently, he is a scientist at Genentech and chair of Roche/Genentech’s global Green Chemistry Technical Working Group.

Preface, Acknowledgments, 1 Introduction to Green Pharmaceutical Science: Fact, Fiction, and Future, 2 Green Chemistry in Drug Development, 3 Development of Green-by-Design, Practical Biocatalytic Processes, 4 Application of Green Metrics to Scalable Industrial Synthesis Plans: Approaches to Oseltamivir Phosphate (Tamiflu R _), 5 The Road to Becoming Green: Process Development of AR-A2, an Active Pharmaceutical Ingredient with Antidepressant Activity, 6 Improved and Greener Process for Pioglitazone and Its Pharmaceutically Acceptable Salts, 7 The Development of a Convergent Green Synthesis of Linezolid, an Oxazolidinone Antibacterial Agent, 8 Development of a Nonaqueous Process for the Synthesis of 3-Amino-pentan-1,5-diol, 9 Development of a Robust, Environmentally Responsible Process for the Manufacture of Tofacitinib Citrate, 10 Selective Nitration under cGMP Conditions, 11 Going Green Using Combined Real-Time Analytics and Process Automation, 12 Approaches to the Scale-Up of Organic Chemistry Using Microwave Heating, 13 Challenges Faced and Future Directions, Index