Immunotoxicity Testing

Immunotoxicology Testing: Past and Future.- Overview and Health-Risk Considerations.- Developmental Immunotoxicity (DIT): The Why, When, and How of DIT Testing.- An In Vivo Tiered Approach to Test Immunosensitization by Low Molecular Weight Compounds.- Risk of Autoimmune Disease: Challenges for Immunotoxicity Testing.- Markers of Inflammation.- Evaluating Macrophages in Immunotoxicity Testing.- Immunotoxicity and Host Resistance Models.- Host Resistance Assays Including Bacterial Challenge Models.- Viral Host Resistance Studies.- Parasite Challenge as Host Resistance Models for Immunotoxicity Testing.- Tumor Challenges in Immunotoxicity Testing.- Testing Protocols in Rodents and Other Laboratory Animals.- The T-Dependent Antibody Response to Keyhole Limpet Hemocyanin in Rodents.- The Sheep Erythrocyte T-Dependent Antibody Response (TDAR).- The Delayed Type Hypersensitivity Assay Using Protein and Xenogeneic Cell Antigens.- The Cytotoxic T Lymphocyte Assay for Evaluating Cell-Mediated Immune Function.- NK Cell Assays in Immunotoxicity Testing.- The Local Lymph Node Assay and Skin Sensitization Testing.- Use of Contact Hypersensitivity in Immunotoxicity Testing.- Evaluation of Apoptosis in Immunotoxicity Testing.- Dendritic Cells in Immunotoxicity Testing.- Evaluating Cytokines in Immunotoxicity Testing.- Flow Cytometry in Preclinical Drug Development.- Enhanced Histopathology Evaluation of Lymphoid Organs.- Immunotoxicity Testing in Nonhuman Primates.- Evaluation in Humans.- Fundamentals of Clinical Immunotoxicology.- Wildlife Testing.- In Vivo Functional Tests for Assessing Immunotoxicity in Birds.- In Vitro Alternatives.- In Vitro Testing for Direct Immunotoxicity: State of the Art.