Advances in Pharmacology (eBook)

Front Cover 1
Advances in Pharmacology, Volume 30 4
Copyright Page 5
Contents 6
Contributors 10
Chapter 1. Neuroprotective Actions of Excitatory Amino Acid Receptor Antagonists 14
I. Introduction 14
II. Glutamate Receptor Subtypes 15
III. Excitotoxicity and Glutamate 22
IV. Ischemia 26
V. Prospects for Clinical Application 29
VI. Molecular Events Associated with Neuroprotection 32
VII. Conclusions 34
References 34
Chapter 2. Pharmacologic Therapy of Obsessive Compulsive Disorder 48
I. Clinical Features of Obsessive Compulsive Disorder 48
II. Biology of OCD 51
III. Pharmacologic Treatment of OCD 52
IV. Summary 60
References 61
Chapter 3. Mechanism of Action of Antibiotics in Chronic Pulmonary Pseudomonas Infection 66
I. Introduction 66
II. Bacterial Biofilms 67
III. Pseudomonas aeruginosa in Cystic Fibrosis 71
IV. Antibiotic Therapy of Intermittent and Chronic Pseudomonas aeruginosa Infection in Cystic Fibrosis 80
V. Conclusions 88
References 88
Chapter 4. Quinolinic Acid in Neurological Disease: Opportunities for Novel Drug Discovery 98
I. General Properties of Quinolinic Acid 98
II. Neurotoxicity of Quinolinic Acid 99
III. Pathways for Quinolinic Acid Biosynthesis 104
IV. Sites of Control of Quinolinic Acid Biosynthesis 110
V. Studies on Quinolinate in Vivo 113
VI. lnhibitors of Quinolinic Acid Biosynthesis 128
VII. Implications for Drug Discovery 130
References 131
Chapter 5. Pharmacologic Management of Shock-Induced Renal Dysfunction 142
I. Introduction to Shock 142
II. Spectrum of Renal Dysfunction in Shock 146
III. Pathophysiology of Acute Renal Failure in Shock 149
IV. Pharmacologic Measures 162
V. Conclusion 190
References 191
Chapter 6. Autoantibodies against Cytochromes P450: Role in Human Diseases 212
I. Introduction 212
II. Diseases for Which No Causative Toxin Was Identified 213
III. Diseases for Which a Causative Drug Has Been Identified 220
IV. Hypotheses for the Appearance and Role of Anti-P450 Autoantibodies 245
V. Conclusions 247
References 249
Chapter 7. Activation and Inactivation of Gene Expression Using RNA Sequences 260
I. Introduction 260
II. Examples of RNA-Mediated Gene Regulation 261
III. Pharmacological Applications of RNAs 267
IV. Concluding Remarks 275
References 275
Chapter 8. Therapy of Cancer Metastasis by Systemic Activation of Macrophages 284
I. Introduction 284
II. Cancer Metastasis 285
III. Macrophages and Homeostasis 287
IV. Tumoricidal Activation of Macrophages 288
V. Macrophage–Tumor Cell Interaction 290
VI. Mechanisms for Macrophage Recognition of Tumor Cells 292
VII. Systemic Activation of Macrophages by Liposomes Containing Immunomodulators 295
VIII. Macrophage Infiltration into Tumors 301
IX. Therapy of Cancer Metastasis in Murine Models 302
X. Optimization and Limitations of Systemic Macrophage Activation-Based Therapy 304
XI. Potentiation of Macrophage Activation for Treatment of Cancer Metastases with Liposome-Encapsulated Agents 306
XII. Multimodality Treatment of Lung Metastases in Murine Models 309
XIII. Therapy of Spontaneous Lung Metastases in Dogs with Osteogenic Sarcoma 312
XIV. Clinical Studies 313
XV. The Place of Macrophage Systemic Activation in Multimodality Protocols 322
XVI. Conclusions 324
References 325
Chapter 9. 5-Hydroxytryptamine Receptor Subtypes: Molecular and Functional Diversity 340
I. Introduction 340
II. G-Protein-Coupled 5-HT Receptors 344
III. 5-HT-Gated Ion Channels-5-HT3 Receptors 376
IV. Conclusion 379
References 380
Index 394
Contents of Previous Volumes 402