Parathyroids (eBook)

Front Cover 1
The Parathyroids: Basic and Clinical Concepts 4
Copyright Page 5
Contents 6
Contributors 10
Preface to the Second Edition 16
Preface to the First Edition 18
Section I: Basic Elements of the Parathyroid System 24
Chapter 1. Parathyroids: Morphology and Pathology 24
Chapter 2. Parathyroid Hormone Biosynthesis and Metabolism 40
Chapter 3. Parathyroid Hormone-Related Protein: Gene Structure, Biosynthesis, Metabolism, and Regulation 54
Chapter 4. Interactions of Parathyroid Hormone and Parathyroid Hormone-Related Protein with Their Receptors 76
Chapter 5. Receptors for Parathyroid Hormone and Parathyroid Hormone-Related Protein: Signaling and Regulation 116
Chapter 6. Nuclear Actions of PTHrP 128
Chapter 7. Signal Transduction of PTH and PTHrP 140
Chapter 8. Receptors and Signaling for Calcium Ions 150
Chapter 9. Immunoassays for PTH and PTHrP: Clinical Applications 166
Section II: Physiological Aspects of the Parathyroid 190
Chapter 10. Physiology of Calcium Homeostasis 190
Chapter 11. Parathyroid Hormone. Anabolic and Catabolic Effects on Bone and Interactions with Growth Factors 206
Chapter 12. Cellular Actions of Parathyroid Hormone on Osteoblast and Osteoclast Differentiation 222
Chapter 13. Physiologic Actions of PTH and PTHrP: I. Skeletal Actions 236
Chapter 14. Physiologic Actions of PTH and PTHrP: II. Renal Actions 250
Chapter 15. Endochondral Bone Formation: Regulation by Parathyroid Hormone-Related Peptide, Indian Hedgehog, and Parathyroid Hormone 268
Chapter 16. Physiologic Actions of PTH and PTHrP: IV. Vascular,Cardiovascular,and Neurologic Actions 284
Chapter 17. Physiologic Actions of PTH and PTHrP: V. Epidermal, Mammary, Reproductive,and Pancreatic Tissues 298
Section III: Clinical Aspects of Primary Hyperparathyroidism 316
Chapter 18. Parathyroid Growth: Normal and Abnormal 316
Chapter 19. Molecular Basis of Primary Hyperparathyroidism 354
Chapter 20. Clinical Presentation of Primary Hyperparathyroidism in the United States 372
Chapter 21. Clinical Presentation of Primary Hyperparathyroidism: Europe 384
Chapter 22. Clinical Presentation of Primary Hyperparathyroidism: India, Brazil, and China 398
Chapter 23. Clinical Course of Primary Hyperparathyroidism 410
Chapter 24. Molecular Markers of Bone Metabolism in Parathyroid Disease 422
Chapter 25. Cytokines in Primary Hyperparathyroidism 434
Chapter 26. Histomorphometric Analysis of Bone in Primary Hyperparathyroidism 446
Chapter 27. Nephrolithiasis in Primary Hyperparathyroidism 460
Chapter 28. Guidelines for the Medical and Surgical Management of Primary Hyperparathyroidism 474
Chapter 29. Medical Management of Primary Hyperparathyroidism 498
Chapter 30. Preoperative Localization of Parathyroid Tissue in Primary Hyperparathyroidism 514
Chapter 31. The Surgical Management of Hyperparathyroidism 526
Chapter 32. Ectopic Locations of Parathyroid Glands 538
Chapter 33. Parathyroid Carcinoma 554
Chapter 34. Acute Primary Hyperparathyroidism 566
Chapter 35. Multiple Endocrine Neoplasia Type 1 574
Chapter 36. Multiple Endocrine Neoplasia Type 2 624
Chapter 37. Familial Forms of Primary Hyperparathyroidism 640
Chapter 38. Familial Benign Hypocalciuric Hypercalcemia and Neonatal Severe Hyperparathyroidism 646
Section IV: Secondary Hyperparathyroidism 664
Chapter 39. The Parathyroids in Renal Disease: Pathophysiology 664
Chapter 40. Renal Bone Diseases: Clinical Features, Diagnosis, and Management 674
Section V: Special Considerations 702
Chapter 41. Evaluation of the Hypercalcemic Patient: Differential Diagnosis 702
Chapter 42. Hypercalcemia Due to PTHrP 710
Chapter 43. Other Local and Ectopic Hormone Syndromes Associated with Hypercalcemia 730
Chapter 44. Genetic Disorders Caused by Mutations in the PTH/PTHrP Receptor: Jansen's Metaphyseal Chondrodysplasia and Blomstrand Lethal Chondrodysplasia 746
Chapter 45. Acute Management of Hypercalcemia 768
Chapter 46. Primary Hyperparathyroidism and Other Causes of Hypercalcemia in Children and Adolescents 782
Section VI: The Hypoparathyroid States 794
Chapter 47. Hypoparathyroidism in the Differential Diagnosis of Hypocalcemia 794
Chapter 48. Magnesium Deficiency in Parathyroid Function 802
Chapter 49. The Molecular Genetics of Hypoparathyroidism 818
Chapter 50. Autoimmune Hypoparathyroidism 830
Chapter 51. Pseudohypoparathyroidism: Clinical, Biochemical, and Molecular Features 846
Chapter 52. Treatment of Hypoparathyroidism 866
Section VII: The Parathyroids in Osteoporosis 874
Chapter 53. Parathyroid Function in the Normal Aging Process 874
Chapter 54. Parathyroid Function and Responsiveness in Osteoporosis 882
Chapter 55. Parathyroid Hormone and Growth Hormone in the Treatment of Osteoporosis 892
Index 904
Color Plate Section 482