Imaging in Biological Research, Part A (eBook)

Cover 1
Table of Contents 6
Contributors to Volume 385 10
Preface 14
Volumes in Series 16
Section I: Imaging in Animal and Human Models 38
1. Positron Emission Tomography: An Advanced Nuclear Medicine Imaging Technique from Research to Clinical Practice 40
2. Biophysical Basis of Magnetic Resonance Imaging of Small Animals 56
3. Nuclear Magnetic Resonance in Laboratory Animals 78
4. Simultaneous Electrophysiology and Functional Magnetic Resonance Imaging Studies in Conscious Rats 100
5. Functional Magnetic Resonance Imaging of Macaque Monkeys 121
6. Atlas Template Images for Nonhuman Primate Neuroimaging: Baboon and Macaque 128
7. Direct Comparison of Visual Cortex Activation in Human and Nonhuman Primates Using Functional Magnetic Resonance Imaging 139
8. Magnetic Resonance Imaging of Brain Function 171
9. Laser-Polarized Xenon Nuclear Magnetic Resonance, a Potential Tool for Brain Perfusion Imaging: Measurement of the Xenon T1 In Vivo 186
Section II: Imaging of Receptors, Small Molecules, and Protein–Protein Interactions 204
10. PET Receptor Assay with Multiple Ligand Concentrations: An Equilibrium Approach 206
11. Estimation of Local Receptor Density, B'max' and Other Parameters via Multiple-Injection Positron Emission Tomography Experiments 221
12. Imaging Dopamine Receptors in the Rat Striatum with the MicroPET R4. Kinetic Analysis of [11C]Raclopride Binding Using Graphical Methods 250
13. Quantitative Analysis of Dopamine D2 Receptor Kinetics with Small Animal Positron Emission Tomography 265
14. Magnetic Resonance Imaging in Biomedical Research: Imaging of Drugs and Drug Effects 277
15. Enzyme-Dependent Fluorescence Recovery after Photobleaching of NADH. In Vivo and In Vitro Applications to the Study of Enzyme Kinetics 294
16. Imaging Myocardium Enzymatic Pathways with Carbon-11 Radiotracers 323
17. Molecular Imaging of Enzyme Function in Lungs 352
18. Brain Uptake and Biodistribution of [11C]Toluene in Nonhuman Primates and Mice 371
19. Optimizing Luciferase Protein Fragment Complementation for Bioluminescent Imaging of Protein–Protein Interactions in Live Cells and Animals 386
20. Mitochondrial NADH Redox State, Monitoring Discovery and Deployment in Tissue 398
Author Index 408
Subject Index 432