Annual Reports on NMR Spectroscopy (eBook)

Front Cover 1
Annual Reports on NMR Spectroscopy 4
Copyright 5
Contents 6
Contributors 10
Preface 12
Chapter 1: Recent Developments in Heteronuclear Multiple-Bond Correlation Experiments 14
1. Introduction 16
2. Theory 17
3. Basic Experiments 19
4. Strategies to Suppress Undesired One-bond Correlations 25
5. HSQC-based Multiple-bond Correlations 28
6. Extending the Scope of Long-range Coupling Constants 33
7. HMBC Experiments for Determining Coupling Constants 39
8. Gamma-HMBC 47
9. Multiplicity Editing of HMBC Spectra 49
10. Indentifying Two-bond Correlations 49
11. 3D NMR Methods Involving HMBC 53
12. New Techniques for Efficient Acquisition 55
13. Covariance Processing of HMBC Spectra 65
14. Other Nuclei 68
15. Conclusion and Outlook 69
References 69
Chapter 2: Two-Dimensional Higher Quantum Correlation and Resolved Techniques for the Analyses of Complex 1H NMR Spectra of Spins 74
1. Introduction 75
2. Theoretical Description of Spin Dynamics in MQ Excitation 82
3. DQ Experiments on 2,3-Dibromopropionic Acid 89
4. Filtering of Spin Systems 94
5. Application to Aromatic Ring Systems Containing a Heteroatom 97
6. Application to Molecules with Two or More Phenyl Rings 100
7. Spin-State-Selected DQ-J-Resolved Sequence 109
8. Spin-selected 3Q-J-Resolved Experiments 116
9. Optimization of tau Delay in SSMQ-J-Resolved Experiments 116
10. Conclusions 119
Acknowledments 119
References 119
Chapter 3: High-Resolution Magic Angle Spinning-Enabling Applications of NMR Spectroscopy to Semi-Solid Phases 124
1. Introduction 125
2. Nature of the Samples and Spectroscopy 125
3. Extending HRMAS Techniques 127
4. Applications to Polymers, Polymer-Supported Systems and Membranes 131
5. Applications to Proteins, Whole Cells and Tissues 135
6. Environmental and Food Applications of HRMAS 140
7. Metabolic Profiling 141
8. Human Metabolites 142
9. Animal and Plant Metabolites 146
References 151
Chapter 4: Accurate Measurement of Small J Couplings 170
1. Introduction 171
2. J-Resolved Spectroscopy for Accurate Measurement 173
3. J-Scaled Spectroscopy for Accurate Measurement 178
4. J-Scaled iMQC Spectroscopy in Inhomogeneous Fields 181
5. Conclusion 191
Acknowledments 191
References 191
Chapter 5: High-Resolution 1H NMR Spectroscopy of Solids 198
1. Introduction 199
2. High-Resolution 1H Spectra without RF Decoupling 207
3. High-Resolution 1H Spectra using RF Decoupling 210
4. Techniques and Applications 220
5. Outlook 231
Acknowledments 231
References 232
Chapter 6: Multiple-Wave-Vector Diffusion-Weighted NMR 238
1. Introduction 239
2. Principles 241
3. Extended and Generalized Theory 259
4. Angular Signal Modulation 286
5. Negative Diffraction Effect 299
6. Summary 304
7. Conclusion 308
Acknowledments 308
References 308
Subject Index 314