Experimental Hematology Today

I Regulation of Stem Cell Proliferation.- 1 Regulation of Stem Cell Proliferation.- Experimental Evidence.- Summary.- References.- 2 Surface Antigens of Hemopoietic Stem Cells: The Expression of BAS, Thy-1, and H-2 Antigens on CFU-s.- Materials and Methods.- Results.- Discussion.- Summary.- Acknowledgments.- References.- 3 The Regulation of Hemopoiesis: Effect of Thymosin or Thymocytes in a Diffusion Chamber.- Materials and Methods.- Results.- Discussion.- Summary.- Acknowledgments.- References.- 4 Anti-CFU-s Activity of Rabbit Anti-mouse Brain Serum: Mechanism of Action.- Materials and Methods.- Results.- Discussion.- Summary.- Acknowledgments.- References.- II Physiology of Committed Stem Cells.- 5 The Control of Neutrophil and Macrophage Production at the Progenitor Cell Level.- Granulocyte-macrophage Colony-forming Cells.- Control by GM-colony-stimulating Factor (GM-CSF).- Nature and Sources of GM-CSF.- Role of Macrophages and Lymphocytes.- GM-CSF and Myeloid Leukemia.- General Comment.- Summary.- Acknowledgment.- References.- 6 The Mononuclear Phagocyte and Its Regulatory Interactions in Hemopoiesis.- Dualism between CSF and Synthetic Prostaglandins.- Cyclic 3?,5-Adenosine Monophosphate in the Mediation of PGE Activity.- Regulation of Granulopoiesis and Macrophage Production by Macrophage-derived PGE.- The Regulatory Role of Macrophages in Lymphopoiesis.- The Macrophage and Other Hemopoietic Cells.- Summary.- References.- 7 Analysis of the Cells Forming Pure and Mixed Erythroid Colonies in Agar after Stimulation by Pokeweed Mitogen-stimulated, Spleen-conditioned Medium.- Materials and Methods.- Results.- Discussion.- Summary.- Acknowledgment.- References.- 8 Current Studies on the Proliferation of Cells of the Mononuclear Phagocyte System.- Origin and Kinetics of Mononuclear Phagocytes.- Regulation of Monocyte Production.- In Vitro Proliferations of Bone Marrow Mononuclear Phagocytes.- Summary.- Acknowledgment.- References.- 9 Colony-forming Cells in the Thymus and Mesenteric Lymph Nodes of Mice Engrafted with Lewis Lung Carcinoma Cells.- Materials and Methods.- Results.- Discussion.- Summary.- Acknowledgment.- References.- III Transplantation Immunology.- 10 Expression of Normal and Leukemia associated Antigens on Blood Cell Malignancies.- Materials and Methods.- Results and Conclusions.- Summary.- Acknowledgment.- References.- 11 Leukocyte Transfusions for the Modification of Host-versus-graft Reactions in Dogs.- Materials and Methods.- Results.- Discussion.- Summary.- Acknowledgment.- References.- 12 Minor Histocompatibility Systems in Dogs.- Materials and Methods.- Results.- Discussion.- Acknowledgments.- Summary.- References.- 13 The Role of Mononuclear Phagocytes in the Defense against Infections and Malignancies.- Macrophages and the Immune Response.- Effects of the Humoral Immune Response on Macrophage Functions.- Effects of the Cell-mediated Immune Response on Macrophage Functions.- Microbiocidal Mechanisms of Macrophages.- Role of Macrophages in the Defense against Neoplastic Disease.- Summary.- Acknowledgment.- References.- 14 Enhancement of Immunological Responses by Methotrexate Pretreatment as a Result of an Eventual Elimination of Suppressor Cells.- Materials and Methods.- Results.- Discussion.- Summary.- Acknowledgment.- References.- 15 Syngeneic and Autologous Bone Marrow Transplantation after Noncurative Chemotherapy with AAFC, DMM, and Cyclophosphamide in Tumor-bearing Mice.- Materials and Methods.- Preparation of Cel Inocula.- Treatment of Bone Marrow Cells with Anti-Thy 1.2 Serum plus Complement.- Immunization Procedures.- X-irradation.- Statistical Analysis.- Experimental Design.- Results.- Discussion.- Summary.- Acknowledgements.- References.- IV Therapeutic Approaches to Aplastic Anemia.- 16 On the Pathogenesis and Treatment of Aplastic Anemia.- Materials and Methods.- Results.- Discussion.- Summary.- Acknowledgements.- References.- 17 Engraftment of HLA Identical Marrow in Treatment of Severe Aplastic Anemia: Results of 110 Consecutive Transplants.- Materials and Methods.- Results.- Discussion.- Summary.- Acknowledgement.- References.- 18 The Role of Cyclophosphamide and Total-body Irradiation in Marrow Transplantation for Severe Aplastic Anemia.- Materials and Methods.- Results.- Discussion.- Summary.- Acknowledgements.- References.- 19 Histocompatibility Testing for Bone- George W. Santos and Saul J. Sharkis marrow Grafting.- The Selection of an HLA-compatible Donor.- Detection of Prior Sensitization.- Summary.- Acknowledgments.- References.- 20 Recent Developments in Histocompatibility Testing in Bone Marrow Transplantation.- What Progress Has Been Made in Recognizing Non-HLA Antigens?.- Platelet Antigens.- H-Y Immunity.- Can HLA-Identical Unrelated Donors Be Used in Bone Marrow Transplantation?.- The Influence of Sensitization on the Effectiveness of Immunosuppression.- Summary.- Acknowledgment.- References.- Summary.- 21 Transplantation of Lymphoid Cells in Patients with Severe Combined Immunodeficiency (SCID).- Characteristics of Patients with SCID.- Grafting of Fetal Tissue.- Grafting of Bone Marrow Tissue.- Immunological Dysregulation Associated with Mild GvHD.- Defects of Precursor T-cells in SCID with B-lymphocytes.- Conclusion.- Summary.- Acknowledgment.- References.- V Treatment of Leukemia.- 22 Experience with Syngeneic Marrow Transplantation in Brown-Norway and Wistar-Furth Rat Models of Acute Myelogenous Leukemia.- Materials and Methods.- Results.- Discussion.- Summary.- Acknowledgment.- References.- 23 Marrow Transplantation for Acute Leukemia.- Summary.- Acknowledgment.- References.- 24 Use of Decontamination and a Protected Environment to Prevent Secondary Disease following Adoptive Immunotherapy of Acute Leukemia in Mice.- Materials and Methods.- Results.- Conclusions.- Summary.- Acknowledgments.- References.- 25 Procurement of Proliferative and Quiescent Acute Leukemia Cells by Centrifugal Elutriation.- Methods.- Results.- Discussion.- Summary.- Acknowledgment.- References.- VI Advances in Experimental Hematology.- 26 Cellular Requirements for Induction of Colony-stimulating Factor in Lymphoid Cell Cultures Stimulated by T- and B-Cell Mitogens.- Materials and Methods.- Results.- Discussion.- Summary.- Acknowledgments.- References.- 27 Serum Blocking Factor-mediated Decrease of T-Cell Immunity Induced by Soluble Histocompatibility Antigens (SHA); Similar Effects of Antibody-free SHA-raised and Hemagglutinating enhancing Sera.- Materials and Methods.- Results.- Humoral Immunity of Mice Treated with SHA.- Discussion.- Summary.- Acknowledgment.- References.- 28 Ultrastructural Analysis of Preserved Dog Granulocytes.- Materials and Methods.- Results.- Discussion.- Summary.- Acknowledgment.- References.- 29 Relationship between Colony-forming Cells in Diffusion Chambers in Vivo (CFU-d) and Colony-forming Cells in Agar in Vitro (CFU-c): 22j Physical Separation and Kinetics in Culture.- Materials and Methods.- Results.- Discussion.- Summary.- Acknowledgments.- References.