Bioorganic and Medicinal Chemistry of Fluorine

Jean-Pierre Begue, PHD, is Emeritus Director of Research at the Centre National de la recherche Scientifique (CNRS) in France. Danièle Bonnet-Delpon, PHD, is Director of Research at CNRS. The authors and their coworkers have developed the chemistry of fluorinated compounds, from organic synthesis to medicinal chemistry.

Foreword. Preface to the English Edition

1 General Remarks on Structural, Physical, and Chemical Properties of Fluorinated Compounds.

1.1 Structural Effects.

1.2 Physical Properties.

1.2.1 Boiling Point.

1.2.2 Surface Tension and Activity.

1.2.3 Polarity-Solubility.

1.2.4 Lipophilicity.

1.3 Effects on Electronic Properties and Reactivity.

1.3.1 Effects of Fluorination on Bond Energies and Reactivity.

1.3.2 Effects of Fluorination on the Electronic Repartition of a Molecule.

1.3.3 Acidity, Basicity, and Hydrogen Bond.

1.3.4 Steric Effects.

1.3.5 Fluorination Effects on the Stability of Reaction Intermediates (Carbocations, Carbanions, and Radicals).

References.

2 Overview on the Preparation of Fluorinated Compounds.

2.1 Preparation of Monofluorinated Compounds.

2.1.1 Nucleophilic Fluorination.

2.1.2 Electrophilic Fluorination.

2.1.3 Formation of Carbon–Carbon Bonds Starting from Monofluorinated Synthons.

2.2 Preparation of Difluorinated Compounds.

2.2.1 Nucleophilic Fluorination.

2.2.2 Electrophilic Fluorination.

2.2.3 Starting from Di- and Trifluoromethyl Compounds.

2.3 Preparation of Trifluoromethyl Compounds.

2.3.1 Fluorination.

2.3.2 Nucleophilic Trifluoromethylation.

2.3.3 Electrophilic Trifluoromethylation.

2.3.4 Radical Trifluoromethylation.

2.3.5 Metal-Catalyzed Trifluoromethylation.

2.3.6 Formation of Carbon–Carbon Bonds from Trifluoromethyl Compounds.

2.4 Synthesis of Perfluoroalkyl Compounds.

References.

3 Effects of Fluorine Substitution on Biological Properties.

3.1 Affinity for the Macromolecule Target.

3.1.1 Steric Effects.

3.1.2 Conformational Changes.

3.1.3 Dipolar Interactions and Electric Field.

3.1.4 Hydrogen Bonds and Other Weak Interactions.

3.1.5 pKa of Amines.

3.1.6 Fluorous Interactions.

3.2 Absorption.

3.2.1 Lipophilicity.

3.2.2 pKa and Solubility.

3.3 Metabolism.

3.3.1 Oxidative Metabolism.

3.3.2 Hydrolytic Metabolism.

3.4 Modification of Chemical Reactivity: Enzyme Inhibitors.

3.4.1 Analogue of Substrates as Inhibitors.

3.4.2 Inhibition by Stabilization or Destabilization of Intermediates of Biological Processes.

3.4.3 Irreversible Inhibition with Mechanism-Based Inhibitors (Suicide Substrates).

References.

4 Fluorinated Analogues of Natural Products.

4.1 Fluorinated Products in Nature.

4.2 Steroids.

4.2.1 Corticosteroids.

4.2.2 Steroids with Trifluoromethyl Groups in Angular Position.

4.2.3 Fluorinated Analogues of Metabolites of Vitamin D3.

4.2.4 Other Fluorinated Steroids.

4.3 Terpenes.

4.3.1 Artemisinin.

4.3.2 Taxol.

4.4 Pigments and Vitamins.

4.4.1 Retinoids.

4.4.2 Carotenoids.

4.4.3 Vitamin D.

4.4.4 Vitamins E and K.

4.4.5 Porphyrins.

4.5 Lipids and Prostanoids.

4.6 Pheromones and Toxins.

4.7 Alkaloids.

4.7.1 Vinca Alkaloids.

4.7.2 Cinchona Alkaloids.

4.7.3 Camptothecin.

4.7.4 Other Fluorinated Alkaloids.

4.8 Macrolides.

4.8.1 Epothilone.

4.8.2 Erythromycin.

4.8.3 Amphotericin B.

4.8.4 Avermectin.

4.9 Anthracyclines.

References.

5 Fluorinated Derivatives of a-Amino Acids and Proteins.

5.1 Fluorinated Aliphatic Amino Acids.

5.1.1 Alanines.

5.1.2 Valines, Leucines, and Isoleucines.

5.1.3 Prolines.

5.2 Aromatic Amino Acids: Phenylalanine, Tyrosine, Histidine, and Tryptophan.

5.3 Functional Fluorinated Amino Acids.

5.3.1 Serines and Threonines.

5.3.2 Aspartic Acids and Arginines.

5.3.3 Glutamic Acids and Glutamines.

5.3.4 Lysine, Ornithine, and Arginine.

5.3.5 Cysteines and Methionines.

5.4 -Fluoroalkyl Amino Acids.

5.4.1 Mono- and Difluoromethyl Amino Acids.

5.4.2 -Trifluoromethyl Amino Acids.

5.5 Incorporation of Fluorinated Amino Acids into Peptides and Proteins.

5.5.1 Polypeptides.

5.5.2 Proteins.

References.

6 Saccharidic Fluorinated Derivatives.

6.1 Glycosyl Fluorides.

6.2 Mono- and Difluorinated Analogues of Sugars.

6.2.1 Fluorinated Furanoses and Nucleosides.

6.2.2 Fluorinated Pyranoses.

6.3 Fluoromethyl Derivatives of Sugars.

6.3.1 Difluorovinyl Compounds.

6.3.2 Difluoromethylene-C-Glycosides.

6.3.3 C-Difluoromethyl Glycosides.

6.3.4 Trifluoromethylated Sugars.

6.4 Perfluoroalkylated Sugars.

6.4.1 Preparation of C-Perfluoroalkyl Sugars.

6.4.2 O- and S-Fluoroalkyl Glycosides.

6.4.3 Applications of Amphiphilic Fluoroalkyl Sugars.

References.

7 Inhibition of Enzymes by Fluorinated Compounds.

7.1 Substrate Analogues.

7.1.1 Fluorine Replaces a Hydrogen Involved in the Catalytic Cycle.

7.1.2 Fluorine Replaces a Hydroxyl.

7.1.3 Fluorinated Analogues of Substrates in Which Fluorine is Not Directly Involved in the Inhibition..

7.2 Destabilization of Reaction Intermediates (or of Transition States) of Enzymatic Processes by Fluorinated Groups.

7.2.1 Prenyl Transfer.

7.2.2 Inhibition of Glycosidases and Glycosyltransferases.

7.2.3 Inhibition of UDP-GlcNAC Enolpyruvyltransferase (MurZ).

7.2.4 Enolpyruvate Shikimate Phosphate Synthase (EPSPS).

7.3 Inhibitors that are Analogues of the Transition State: Di- and Trifluoromethyl Ketones.

7.3.1 Serine Enzymes.

7.3.2 Inhibition of Aspartyl Enzymes.

7.3.3 Inhibition of Metalloproteases.

7.3.4 Cysteine Protease and Thiol Enzymes.

7.4 Mechanism-Based Inhibitors.

7.4.1 Inhibition of Pyridoxal Phosphate Enzymes.

7.4.2 Thymidylate Synthase.

7.4.3 Inhibition of Monoamine Oxidases.

7.4.4 D-Ala-D-Ala Dipeptidase (VanX).

7.4.5 Inhibition of Ribonucleotide Diphosphate Reductase.

7.4.6 Inhibition of S-Adenosylhomocysteine Hydrolase.

7.4.7 Inhibition of Cytidine-50-diphosphate-D-Glucose.

4,6-Dehydratase (CDP D-Glucose 4,6-Dehydratase).

7.4.8 Other Irreversible Inhibitors.

7.5 Fluorinated Inhibitors Involving a Still Unknown Mechanism.

7.5.1 Inhibition of the Steroid C17(20)lyase.

7.5.2 Phosphatidylinositol Phospholipase C (PI-PLC).

7.5.3 Inhibition of the Protein of Transfer of Cholesteryl Esters.

7.5.4 -Fluoropolyamines as Inhibitors of the Biosynthesis of Polyamines.

7.5.5 Inhibition of the Biosynthesis of Cholesterol.

References.

8 Fluorinated Drugs.

8.1 Antitumor and Antiviral Fluorinated Drugs.

8.1.1 Fluoronucleosides.

8.1.2 Other Antitumor and Antiviral Drugs.

8.2 Anti-infectious Drugs.

8.2.1 Fluorinated Antibiotic Drugs.

8.2.2 Antifungal Drugs.

8.2.3 Fluorinated Drugs for Parasitic Diseases.

8.3 Drugs for CNS Disorders.

8.3.1 Neuroleptics.

8.3.2 Drugs for Depressive Disorders.

8.3.3 Anxiolytics and Sedatives.

8.3.4 Other Drugs for CNS Disorders.

8.4 Drugs of Inflammatory and Immunity Disorders.

8.4.1 Fluorocorticosteroids.

8.4.2 H1 Antagonist Antiallergics.

8.4.3 Drugs for Asthma and Respiratory Disorders.

8.4.4 Analgesic and Antiarthritic Drugs.

8.5 Drugs for Cardiovascular Disorders.

8.5.1 Cholesterol Lowering Drugs.

8.5.2 Drugs for Hypertension.

8.5.3 Drugs for Arrhythmias.

8.5.4 Antithrombosis and Anticoagulant Fluorinated Agents.

8.6 Drugs for Gastrointestinal Disorders.

8.6.1 Prevention and Treatment of Ulcer.

8.6.2 Antiemetic Agents.

8.6.3 Drugs for Bowel Disorders.

8.7 Drugs for Endocrine and Metabolic Disorders.

8.7.1 Drugs Acting on Steroid Hormone Receptors.

8.7.2 Drugs for Benign Prostatic Hypertrophy (BPH).

8.7.3 Drugs for Other Urologic Disorders.

8.7.4 Drugs for Calcemia Disorders.

8.7.5 Drugs for Diabetes.

8.7.6 Drugs for Hepatic Disorders.

8.8 Miscellaneous.

8.8.1 Drugs for Ophthalmic Disorders.

8.8.2 Drugs for Genetic Disease.

8.8.3 Contrast and Diagnostic Agents.

8.9 Highly Fluorinated Compounds with Clinical Uses.

8.9.1 General Anesthetics.

8.9.2 Therapeutic Uses of Perfluorocarbons.

8.10 Fluorinated Functions and Motifs in Medicinal Chemistry.

8.10.1 Fluorinated Ethers.

8.10.2 Fluorinated Alcohols and Amines.

8.10.3 Fluorinated Ketones.

8.10.4 Fluoroalkyl Groups.

Appendix: INN and Trademark Names.

References.

Index.