Clinical Cancer Genomic Medicine

Dr. Claire Morgan is Associate Professor in cancer genetics and the Programme Director for the MSc Genomic Medicine course. As the Programme Director, established and leads the first fully NHS-supported Genomic Medicine course in Wales; serves as an invited member of Genomics Partnership Wales and Wales Gene Park Strategic Advisory group and the Genomic Medicine UK advisory Group. In addition, Programme Director for the BSc Genetics and Medical Genetics degree schemes and teaches on all the UG degree schemes including the Genetics/ Medical Genetics/Applied Medical Sciences and Population Health and Medical Sciences BSc degree schemes in the School of Medicine. Professor Maher is an international authority in clinical cancer genetics and genomics. His vast experience and in-depth knowledge of basic genetics and molecular biology in key cancer family syndromes are unparallel. He would closely supervise and guide on the development of this important volume in the series.

Section I: Fundamentals of Cancer genetics and genomics 1. The human genome- organisation & function 2. Introduction to cancer genetics 3. Oncogenes and tumour suppressor genes 4. Cancer epigenomics 5. Cancer and the microbiome- the Oncobiome 6. Cancer immunogenomics 7. Cancer pharmacogenomics 8. Genomic Technologies for Tumour Profiling 9. New emerging technologies- The liquid biopsy 10. Gene and genome editing 11. Bioinformatics for Cancer Genome Analysis Section II: Clinical cancer genetics and genomics 1. Classification and epidemiology of the genetic and inherited cancer- hereditary cancer family syndromes 2. Breast and ovarian cancer including endometrial cancer 3. Gastrointestinal malignancies- oesophagus, colo-rectal, heapto-biliary and pancreatic 4. Central nervous system tumours 5. Neoplasia of endocrine system (Solitary and multiple) 6. Ocular tumours- retinoblastoma 7. Hematological cancer and lympho-reticular malignancy 8. Oro-pharyngeal and lung cancers 9. Malignant melanoma and related skin neoplasia 10. Childhood tumours and paediatric malignant neoplasia disorders 11. Malformation syndromes with neoplasia Section III: Clinical cancer genomic medicine 1. Integration of cancer genomics in clinical medicine 2. Cancer genetic counselling 3. Diagnostic cancer genomic laboratory- organization & function/ cancer database 4. Targeted therapy and screening in cancer genomic / precision medicine 5. Surgical approaches in clinical cancer genetics and genomics 6. Ethical, Legal and Social Implications of cancer genomic testing 7. The future of cancer in the context of the genomics era