Progress in Medicinal Chemistry

Topics of general interest to medicinal chemists, microbiologists, pharmacologists and clinicians are reviewed in this volume. The subjects examined include phosphodiesterase type IV inhibitors and therapeutic potential in the treatment of asthma.

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Seven topics of general interest to medicinal chemists, microbiologists, pharmacologists and clinicians are reviewed. The subjects examined are: phosphodiesterase type IV inhibitors and therapeutic potential in the treatment of asthma; the mode of action and biosynthesis of the immunosuppressant cyclosporins; the present status of carbapenems in the treatment of bacterial infection; the treatment of breast cancer by inhibiting aromatase; a new class of potentially useful antipsychotics; and the role of protein tyrosine kinases and their inhibition of cell multiplication by a wide variety of compounds.