Progress in Drug Metabolism

Potential applications for transgenic animals in drug development, H.D. Liggitt et al; role of molecular biology in the structural and functional characterization of the UDP-glucuronosyltransferases, M.W.H. Coughtrie; molecular analysis of cytochrome P450s in the CYP2 gene family, C.J. Henderson and C.R. Wolf; CNS penetration of drugs - importance of physiochemical properties, S. Jezequel; azoreduction of drugs an other xenobiotics, W.G. Levine; skin as a xenobiotic metabolizing organ, S.A.M. Hotchkiss; the role of the pharmacokinetic and metabolism studies in anticancer drug discovery and development, A. Gescher and D.R. Newell; the in vivo relevance of in vitro genotoxicity assays incorporating enzyme activation systems, R.D. Combes.