Advances in Cardiovascular Technology

Jamshid H. Karimov, MD, PhD, FAHA, FACC is a cardiac surgeon, researcher, inventor and author with extensive experience in device therapies for heart failure, mechanical circulatory support, total artificial hearts, cardiac replacement, and minimally invasive cardiac surgical techniques. He is currently affiliated with the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, and the Department of Biomedical Engineering, Molecular Medicine, Cleveland Clinic Lerner Research Institute. Dr. Karimov’s research interests and innovative work focus on development of simple surgical devices, new methodologies, advanced cardiac therapies, and platform technologies for cardiovascular applications. As an inventor and Principal Investigator, Dr. Karimov conducted first-in-man efforts at Cleveland Clinic. He has achieved the longest in vivo duration for continuous flow total artificial heart implantation. He has also introduced innovative methods for intraoperative cardiac device management and designed new cardiovascular devices. Kiyotaka Fukamachi, MD, PhD, is a cardiovascular surgeon by training and has been working full-time in research since joining Cleveland Clinic in 1990. He is Director of the Cardiovascular Dynamics Lab and Section Head of Biomechanical Devices in the Cleveland Clinic Department of Biomedical Engineering. He is also a Professor in the Department of Biomedical Engineering and Department of Molecular Medicine at Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. Dr. Fukamachi has extensive experience in the development and evaluation of mechanical circulatory support devices such as the Cleveland Clinic-Nimbus total artificial heart (TAH), CorAide™ left ventricular assist device (LVAD), MagScrew TAH and LVAD, PediPump™ pediatric circulatory assist device, DexAide right ventricular assist device (RVAD), continuous-flow TAH (CFTAH), and the pediatric version of the CFTAH (P-CFTAH). He has also been involved in simple cardiac devices such as the Coapsys® and the Gillinov/Cosgrove AtriCure AtriClip. Over the course of his career, he has accumulated nearly 300 scientific publications, 254 abstracts, and 330 presentations. Marc Gillinov, MD, is Chair of the Cleveland Clinic Department of Thoracic and Cardiovascular Surgery. Since joining Cleveland Clinic in 1997, Dr. Gillinov has become one of the nation’s busiest heart surgeons. He specializes in robotic and minimally-invasive heart valve repair and replacement. His patients range from Academy Award winner Robin Williams to his long-time barber, Vince. A prolific researcher, Dr. Gillinov has more than 450 scientific publications to his credit and has been instrumental in the development of medical devices and treatments that enhance the care of cardiac patients. Spurred by patients’ questions, Dr. Gillinov extended his efforts to help people achieve heart health by teaming with Cleveland Clinic cardiologist Dr. Steven Nissen to write the myth-busting book, “Heart 411: The Only Heart Guide You Will Ever Need.” He also appears on WJW-TV, Fox 8 Cleveland, as “Dr. Marc.” Dr. Gillinov is thrilled and honored to work with the nation’s number one heart team (27 years in a row!) to improve the heart health of people from around the country and around the world.

Part I: Cardiovascular practice 1. The history of cardiac device innovation: the collaborative triumph of the Kay-Cross Oxygenator 2. The critical need for ongoing innovation in cardiovascular medicine

Part II: Cardiovascular perfusion 3. Progress in cardiovascular perfusion and technology 4. Organ perfusion and cardiopulmonary bypass techniques

Part III: Mechanical circulatory support and organ replacement 5. Demand for mechanical circulatory support 6. Continuous-flow ventricular assist devices 7. Research and development for creating a universal ventricular assist device 8. Right ventricular assist device 9. Advanced approaches for total artificial heart development 10. Cardiac transplantation and organ preservation 11. Extracorporeal membrane oxygenation in adults 12. Device-based circulatory support therapy for heart failure with preserved ejection fraction

Part IV: Innovative surgical approaches and interventional techniques 13. Cardiac implantable devices in heart failure: role of imaging 14. Imaging technologies and virtual planning for congenital heart repairs 15. Evolution of device therapies for cardiovascular surgical care in children 16. Robotic mitral valve surgery: new techniques and solutions 17. Transcatheter aortic valve procedures: technology update 18. Technology advancement for percutaneous interventions for mitral regurgitation 19. Transcatheter mitral valve replacement: technology update 20. Novel developments in tricuspid valve assessment and treatments 21. Innovative surgical techniques for complex aortic repair 22. Innovative technologies for hybrid cardiovascular repair 23. Intraoperative cardiac deairing: new concept and technology

Part V: Treatment of cardiac rhythm disturbances 24. Cutting-edge technologies for cardiac rhythm treatment: recent progress of catheter ablation using radiofrequency current and pulsed electric field 25. Modern technologies for cardiac resynchronization therapy 26. Innovative approaches and technology platforms for pacemaker lead extraction 27. Surgical devices for cardiac radio-frequency ablation 28. Novel devices for epicardial left atrial appendage management 29. Technology for surgical cardiac cryoablation procedures

Part VI: Hemodynamic patient monitoring 30. Basic hemodynamic parameters 31. Wearable technologies for cardiac monitoring 32. Intelligent systems and smart devices for the continuous monitoring of cardiac hemodynamics 33. Microcirculation and tissue perfusion assessments for complex cardiovascular disease care 34. Technologies for hemodynamic measurements: past, present and future

Part VII: Future directions of cardiovascular technology 35. Cardiovascular device markets: where do we go now? 36. Innovation in cardiovascular bioelectronics 37. Diagnostics and prevention: landscape for technology innovation in precision cardiovascular medicine 38. Devices that enhance the biomechanics of the failing heart 39. Advancement of technology and innovation for future cardiovascular care