Anticipatory Ethics and The Use of CRISPR in Humans

lt;p> Michael W. Nestor received his Ph.D. in Neuroscience from The University of Maryland, School of Medicine and has dual certificates in Regulatory Affairs-Medical Devices and Pharmaceuticals from RAPS and a certificate in Project Management from the University of California, Irvine. He completed postdoctoral fellowships at the National Institutes of Health and The New York Stem Cell Foundation, where he was also a Staff Scientist. Concurrently, Michael was an NIH IRACDA Fellow at Rutgers University, focused on teaching in minority-serving institutions and helping increase the participation of traditionally underrepresented groups in science. Dr. Nestor was awarded an American Association for the Advancement of Science, Science and Technology Policy Fellowship and served in the executive branch.

A neuroscientist with 20 years of research experience, Dr. Nestor was Director of Neural Stem Cell Research at The Hussman Institute for Autism, where he led his laboratory studying autism by creating brain organoids from human induced pluripotent stem cells. His lab developed multiplexed high-throughput CRISPR and drug-screening platforms using human stem cell derived brain organoids. Michael ran his own human stem cell consulting company, Synapstem, and acted as a venture advisor to the UM Momentum Fund and the Abell Foundation and as Co-Chair of the Neural Stem Cell Working Group at the University of Maryland, School of Medicine.

Richard L. Wilson teaches philosophy and ethics in the Philosophy and Computer and Information Sciences Departments at Towson University. He is a Senior Research Scholar in the Hoffberger Center for Professional Ethics at the University of Baltimore. Professor Wilson specializes in Applied Ethics and has taught a wide variety of Applied Ethics Classes. As a specialist in Applied Ethics, he has taught courses and published a variety of books and articles in Engineering Ethics, Computer Science Ethics, Biomedical Ethics, Business Ethics, Media Ethics, and Environmental Ethics. Recent publications include a book, Glossary of Cyber Warfare, Cyber Crime and Cyber Security, with a variety of papers published including 3D Printing and Anticipatory Business Ethics, An Anticipatory Ethical Analysis of Offensive Cyberspace Operations, The Use of Facial Recognition in China's Social Credit System: An Anticipatory Ethical Analysis, Anticipatory Medical Ethics: Pharmaceuticals and Nanotechnology, and The Ethics of Autonomy and Lethality. His most recent publications include: Anticipatory Ethics as a Method for Teaching Engineering Ethics in the ASEE Proceedings and Smart Cities and Cyber Security: Ethical and Anticipated Ethical Concerns.

Chapter 1: Brief Introduction to CRISPR Cas 9.- Chapter 2: Introduction To Anticipatory Ethics.- Chapter 3: CRISPR, Phenomenology and Lived Experience.- Chapter 4: CRISPR and the Concept of Personhood.- Chapter 5: The use and access to CRISPR in historically socio-economically disadvantaged and marginalized communities.- Chapter 6: Future use of CRISPR: Gene Drive.- Chapter 7: Future use of CRISPR II: CRISPR Kill Switches.- Chapter 8: Domestic and International Regulation of CRISPR.- Chapter 9: Policy Recommendations with respect to CRISPR Germline Editing in Humans.- Chapter 10: Conclusions.