Carbohydrate Chemistry

Dr Yves Queneau, Research Director at CNRS, is Head of the Organic and Bioorganic Chemistry Laboratory at INSA Lyon, Deputy-Director of the “Institut de Chimie et Biochimie Moléculaires et Supramoléculaires” (ICBMS), University of Lyon, France and Honorary Professor at the University of Hull, UK. After his doctorate on aqueous Diels-Alder reactions involving glycodienes under the supervision of Professor André Lubineau (Orsay, 1988) he was appointed as CNRS fellow and worked on cycloaddition reactions towards complex sugars. He then spent one year in 1992 in Professor Samuel J. Danishefsky’s group in Memorial Sloan Kettering Cancer Center in New York, USA. He later moved to Lyon in a mixed CNRS-industrial research facility dedicated to sucrose chemistry (1995-2003) before joining its present position where he develops his research in organic and biological chemistry with a particular interest for the use of carbohydrates as renewable raw materials.

Applications of fluorous tag methodology in carbohydrate synthesis;

Recent progress in the glycosylation of lupanes;

Synthetic routes targeting agrocinopines, bacterial carbohydrate phosphodiesters, and their analogues;

Glycosylation in the green chemistry era;

Sonogashira cross-coupling on carbohydrate templates;

Recent advances in the functionalization of unprotected carbohydrates;

Catalytic access to anhydrohexitols and their isomerization;

In situ formation of nucleotide-sugars from simple substrates for glycosyltransferase-catalyzed reactions;

Enzymes as synthetic tools for the production of pentose-based molecules of interest;

Sugar-based organogelators;

Chemical synthesis of oligosaccharides on soluble support;

Disaccharides as building blocks for novel glycomacrocycles;

Synthesis and properties of photosensitive glycomacrocycles;

Cyclopeptides as glycan-presenting multivalent scaffolds;

FimH antagonists prevent biofilm formation on catheter surfaces;

Recent progress in O-acetylated gangliosides analysis and functions in cancer;

The cell wall pectic rhamnogalacturonan II, an enigma in plant glycobiology;

Diagnostic glycotools;

Recent advances in the radiation chemistry of destructured starch and other glucans as model compounds;

Polyester thermosets from carbohydrates