Cerebrospinal Fluid and Subarachnoid Space

R. Shane Tubbs, MS, PA-C, PhD is a native of Birmingham, Alabama, USA and a is a clinical anatomist, author, editor, educator, and researcher. He is Professor of Neurosurgery, Neurology, Surgery, and Structural & Cellular Biology, Director of Surgical Anatomy at Tulane School of Medicine and Program Director of Anatomical Research in the Clinical Neuroscience Research Center at Tulane University School of Medicine, New Orleans, Louisiana and Department of Neurosurgery and Ochsner Neuroscience Institute Ochsner Health System, New Orleans, LA. He has multiple honorary professorships/faculty positions both in the US and abroad. Dr. Tubbs is President-elect of the American Association of Clinical Anatomists (AACA) and serves as its Journal’s (Clinical Anatomy) Editor-in-Chief. Dr. Tubbs’ research interests are centered around what has been termed “reverse translational anatomy research” where clinical/surgical problems are identified and solved/explained with anatomical studies. This investigative paradigm in anatomy has resulted in over 1,800 peer reviewed publications from his laboratory. Dr. Tubbs’ laboratory has made novel discoveries in human anatomy and in 2018, he was listed as a “hyperprolific author” in the journal Nature. Dr. Tubbs sits on the editorial board of over 10 anatomical journals and over 30 clinical journals and has reviewed for over 150 various scientific journals. He has authored/edited over 50 books and over 80 book chapters primarily in anatomical and neurosurgical textbooks. Lastly, Dr. Tubbs is Chair of the Federative International Programme on Anatomical Terminologies (FIPAT) and oversees six working groups dedicated to this topic. Under his leadership, the second edition of Terminologia Anatomica was just published. Joe Iwanaga, DDS, PhD, is a clinical anatomist and an oral and maxillofacial surgeon. He is the author of more than 400 articles in peer-reviewed journals. Dr. Iwanaga is a Councilor-at-Large of the American Association of Clinical Anatomists, and Coordinator of the FIPAT Oral Anatomy Working Group of the International Federation of Associations of Anatomists. He is a Dental, Oral and Maxillofacial Section editor of the journal Clinical Anatomy. Dr. Rizk is a neurosurgeon at the Penn State Hershey Medical Center with a clinical specialty in pediatric peripheral nerve surgery. He has multiple publications on the PNS and is active in basic science research regarding peripheral nerve regeneration. Anthony V. D'Antoni works in the Department of Radiology at Weill Cornell Medicine, New York, NY, USA. Aaron S. Dumont works at Tulane University in New Orleans, Louisiana, USA.

1. Historical perspectives
2. Development of the ventricles, choroid plexus and subarachnoid space
3. Anatomy of the ventricles and subarachnoid spaces and cisterns
4. Anatomy of choroid plexus, capillary endothelial cells, ependymal layer, pia and arachnoid granulations/villi, extracellular space
5. Spinal punctures
6. CSF in the animal kingdom
7. Animal models for CSF testing
8. CSF physiology: Production, circulation, absorption, function, extrachoroidal formation/absorption
9. CSF and basal lymphatic system in mammals
10. A new look at CSF circulation
11. Virchow Robin spaces
12. CSF and disposition of alpha synuclein
13. CSF in pediatrics: prematurity, neonates, infants, and toddlers
14. CSF imaging
15. CSF in neurodegenerative disease processes
16. CSF in trauma
17. CSF in pregnancy
18. CSF in space, high-altitude or deep sea diving
19. CSF fluid replacement
20. Glymphatic system and CSF
21. Lymphatic system and CSF
22. Blood brain barrier
23. Intracranial/intraspinal pressure
24. Intracranial pressure (ICP) in trauma and autoregulation
25. ICP in slit ventricle syndrome
26. ICP and over drainage
27. Non invasive ICP monitoring
28. NPH
29. ICP in normal pressure hydrocephalus (NPH)
30. Neuropsychological testing and NPH
31. Shunt infections
32. Shunt complications
33. Drugs and CSF production and ICP
34. Hydrocephalus treatment “historical perspective”
35. Hydrocephalus and shunt valves
36. Reasons for shunting and revision surgery: UK registry data
37. Infections of CSF
38. CSF and disease:
39. CSF and headaches
40. CSF markers and exosomes
41. CSF in Chiari I malformation
42. CSF in Chiari II malformation
43. Neurophysiological consequences of hydrocephalus
44. Hemorrhage and hydrocephalus
45. Arrested hydrocephalus
46. Aqueductal stenosis
47. Hydrocephalus and genetic disorders
48. Biomarkers of hydrocephalus
49. Long-term prognosis of fetal hydrocephalus
50. Circumventricular organs
51. Endoscopic third ventriculostomy and choroid plexus coagulation
52. Failure of ETV
53. Learning disabilities in hydrocephalus
54. Hydrocephalus in craniosynostosis
55. Syringomyelia
56. Arachnoid cysts
57. Neuro endoscopic anatomy
58. Endoscopy technique
59. Hydrocephalus in the developing world
60. Economics of hydrocephalus
61. Hydrocephalus and Fetal surgery for myelomeningocele
62. Ventricular anatomy in Chiari II malformation
63.Venous outflow obstruction and hydrocephalus
64. CSF markers before and after shunting
65. Spinal CSF compartments
66. Ventricular access devices in neonatal hemorrhage
67. Body position and lumbar CSF leak
68. Spontaneous CSF leak
69. Visual pathway and hydrocephalus
70. Effect of decompressive craniectomy on CSF pulsatility
71. Direct control of CSF pulsatility and its effect on cerebral blood Flow
72. The pulsating brain
73. Choroid plexus transport
74. Amyloid, tau, alpha synuclein and CSF dynamics