Diagnosis and Management in Dementia

Colin R. Martin RN, BSc, MSc, PhD, MBA, YCAP, FHEA, C.Psychol, AFBPsS, C.Sci is Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director of the Institute of Health and Wellbeing at the University of Suffolk, UK. He is a Chartered Health Psychologist and a Chartered Scientist. He also trained in analytical biochemistry, this aspect reflecting the psychobiological focus of much of his research within mental health. He has published or has in press well over 300 research papers and book chapters. He is a keen book author and editor having written and/or edited more than 50 books. These outputs include the prophetic insight into the treatment of neurological disease, Handbook of Behavior, Food and Nutrition (2011), Nanomedicine and the Nervous System (2012), Oxidative Stress and Dietary Antioxidants in Neurological Disease (2020), Zika Virus Impact, Diagnosis, Control and Models (2021), Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior and Diet (2021), Diagnosis and Treatment of Spinal Cord Injury (2022), The Neurobiology, Physiology, and Psychology of Pain (2022) and The Handbook of Lifespan Cognitive Behavioral Therapy: Childhood, Adolescence, Pregnancy, Adulthood, and Aging (2023). Professor Martin is particularly interested in all aspects of the relationship between underlying physiological substrates and behavior, particularly in how these relationships manifest in both acute and chronic psychiatric disorder. He has published original research germane to significant mental health disorders including the areas of schizophrenia, anxiety, depression, self-esteem, alcohol and drug dependency, high secure forensic mental health and personality disorder. He has a keen interest in the impact of postviral illness and is actively involved in clinical research post-Covid pandemic and in particular, the impact of Long Covid on psychological, neurological, physiological and social functioning. He is involved in collaborative International research with many European and Non-European countries. Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRSC, FRCPath graduated with an Honours Degree in Biology and Physiology with Pharmacology. After gaining his University of London PhD, he received his Membership of the Royal College of Pathologists. He was later awarded his second doctorate (DSc), for his contribution to protein metabolism in health and disease. He is Professor of Clinical Biochemistry (Hon) at King’s College Hospital and Emeritus Professor of Nutritional Biochemistry at King’s College London. He has Honorary Professorships at the University of Hull, and the University of Suffolk. Professor Preedy was the Founding Director and then long-term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy has been awarded fellowships of the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health, the Royal Society for Public Health, the Royal Society of Chemistry and the Royal Society of Medicine. He carried out research when attached to the National Heart Hospital (part of Imperial College London), The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with international research groups in Finland, Japan, Australia, USA, and Germany. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and edited books.

Section 1 Dementia: Introductory Chapters 1. A review of the different types of dementia2. The classification of dementia: problems and challenges3. Alzheimer’s disease: an overview4. Dementia and competing hypothesis – the example of Alzheimer’s disease and its various hypotheses5. Lewy body dementia – an overview6. Mixed dementia – an overview7. Vascular dementia – an overview8. Linking in physical activity and dementia9. Risk factors in dementia10. Mortality in dementia – linking in delirium11. Rare forms of dementia12. Prion diseases and dementia13. Dementia in Parkinson disease14. Dementia in traumatic brain injury15. Risk factors in dementia – towards a coherent theory of dementia16. Genetics of dementia

Section 2 Biomarkers, Psychometric Instruments, and Diagnosis 17. Circulating biomarkers in neurodegenerative dementias – YKL-40 and beyond18. Salivary biomarkers in Alzheimer’s disease19. Use of cerebrospinal fluid in diagnosis of dementias20. SPECT perfusion imaging in assessment of neurodegenerative dementias21. Computerised tomography (CT) in assessment of neurodegenerative dementias22. Magnetic resonance imaging (MRI) in assessment of neurodegenerative dementias23. Questionnaires: The mini-mental state examination (MMSE) and beyond24. The Cambridge Mental Disorders of the Elderly Examination (CAMDEX) and applications to dementia25. The Montreal Cognitive Assessment (MoCA) and applications to dementia26. The Hopkins Verbal Learning Test (HVLT) and applications to dementia27. The Addenbrooke’s Cognitive Examination (ACE) and applications to dementia28. ALBA Screening Instrument (ASI) and applications to dementia29. The prediction of Alzheimer’s disease

Section 3 Pharmacological Treatments for Dementia30. Cholinesterase inhibitors in dementias – an overview31. NMDA receptor antagonists in dementia – an overview32. Donepezil usage – a focused review33. Rivastigmine usage – a focused review34. Galantamine usage – a focused review35. Memantine – a focused review36. Failures and successes of monoclonal antibodies – bapineuzumab and beyond37. Immunotherapies: an overview

Section 4 Non-Pharmacological Treatments38. Internet counselling39. Counselling in dementia40. Cognitive rehabilitation in dementia41. Cognitive stimulation in dementia42. Anodal Transcranial Direct Current Stimulation43. Nanoparticles: nanodiamond treatment in Alzheimer’s disease44. Increasing intakes and improving nutritional status in dementia45. All-trans retinoic acid in Alzheimer’s disease46. Environmental enrichment in dementia47. Music therapy in dementia48. Aromatherapy in dementia49. Massage in dementia50. Dancing in dementia51. Multisensory Stimulation in Dementia52. Animal-assisted therapy in dementia53. Occupational therapy in dementia