Handbook of Physiology

This important volume provides a cogent analysis of basic principles. The chapters on anatomy of the kidney focus on ultrastructure, providing a basis for understanding the following descriptions of transport across membranes and through intercellular channels. The discussion of investigative techniques begins with an assessment of clearance methods in animals and continues with an analysis of the techniques of stop flow, micropuncture, and in vitro perfusion of isolated tubule segments. Acidification and ammonia excretion are presented in depth, as are discrete tubular transport processes and electrophysiology. Other topics include glomerular-tubular balance, the role of aldosterone in electrolyte transport of antidiuretic hormone on water movement, and seminal views by key investigators on blood flow and filtration. Comparative physiology is also discussed, along with the renin-angiotensin system, the physiology of diuretic agents, and even the conduit system out of the kidney proper.