Heat Shock Proteins in the Immune System

Pramod K. Srivastava, Department of Immunology, University of Connecticut Health CenterRobert J. Binder, Department of Immunology, University of Pittsburgh

Introduction and history.- Part I: Structure of the HSPs in relation to chaperoning peptides and proteins.- Chapter 1: Hsp70-subsrate interactions.- Chapter 2: Molecular Chaperone Inhibitors.- Part II: Exposure of HSPs to immune cells.- Chapter 3: Extracellular Heat Shock Proteins as Stress Communication Signals.- Part III: Regulation of immune responses by extracellular HSPs.- Chapter 4: The Heat Shock Protein-CD91 pathway and Tumor Immuno-surveillance.- Chapter 5: Bridging the gaps in the vaccine development: Avant-garde vaccine approach with secreted heat shock protein gp96-Ig.- Chapter 6: Regulation of the Extracellular Matrix by Heat Shock Proteins and Molecular Chaperones.- Chapter 7: Heat shock protein mediated T cell responses in pathogen infections.- Chapter 8: An ancestral immune surveillance system in the amphibian Xenopus connecting certain heat shock proteins with classical and nonclassical MHC class I molecules.- Chapter 9: Inhibition of HSPs for Enhanced Immunity.