Cell-Penetrating Peptides

Classes and prediction of cell-penetrating peptides.- Penetratin story : an overview.- Testing membrane interactions of CPPs.- Interactions of amphipathic CPPs with model membranes.- NMR studies of three-dimensional structure and positioning of CPPs in membrane model systems.- Measurements of the intracellular stability of CPPs.- Tools for predicting binding and insertion of CPPs into lipid bilayers.- Studies of proteoglycan involvement in CPP-mediated delivery.- Uptake Kinetics of cell-penetrating peptides.- Thermodynamics of lipid interactions with cell-penetrating peptides.- Calcium and membrane repair.- Mapping of protein transduction pathways with fluorescent microscopy.- Insight into cell-entry mechanisms of CPPs by electron microscopy.- Toxicity methods for CPPs.- Comparison of CPP uptake methods.- Characterization of cellular internalization pathways for CPP-mediated oligonucleotide delivery.- Mimicry of protein function with cell-penetrating peptides.- Homeoprotein intercellular transfer, the hidden face of cell-penetrating peptides.- Pharmacology, biodistribution, and efficacy of GPCR-based pepducins in disease models.- Identification and Characterization of Tissue-Specific Protein Transduction Domains using Peptide Phage Display.- Applications of Cell Penetrating Peptides as Signal Transduction Modulators for the Selective Induction of Apoptosis.- Splice Redirection as a Convenient Assay to Monitor CPP-ON Efficiency and Mechanism.- CPP directed oligonucleotide exon skipping in animal models of Duchenne muscular dystrophy.- PTD-DRBD siRNA delivery.- A non-covalent peptide-based strategy for siRNA delivery.- Application of PepFect peptides for the delivery of splice correcting oligonucleotides.- Internalization of nucleoside phosphates into live cells by complex formation with different CPPs and JBS-Nucleoducin.- Enhanced cellular delivery of cell-penetrating peptide –peptide nucleic acid conjugates by photochemical internalization (PCI).- Identificationof homing peptides using the in vivo phage display technology.- Measuring the action of CPP-siRNA conjugates in the lung.- Intracellular delivery of nanoparticles with CPPs.- Multifunctional CPP polymer system for tumor-targeted pDNA and siRNA delivery.- Cell Penetrating Penta-Peptides (CPP5s) and Bax Inhibiting Peptides (BIPs): Protocol for their application.- PAIR technology: exon-specific RNA binding protein isolation in live cells.- Quantitation of cellular and topical uptake of luciferin oligoarginine conjugates.- Industrial-scale manufacturing of a possible oligonucleotide cargo CPP based drug.- Application of a fusiogenic peptide GALA for intracellular delivery.- Therapeutic Applications of Cell-Penetrating Peptides.- Nonclinical and clinical experiences with CPP-based self assembling peptide systems in topical drug development.