Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C−H Bonds (eBook)
XXIII, 144 Seiten
Springer International Publishing (Verlag)
978-3-319-38878-6 (ISBN)
This thesis reports the latest developments in the direct amination of various C−H bonds using an H−Zn exchange/electrophilic amination strategy. McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines.
The material outlined in this book shows how McDonald achieved C−H zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst and O-benzoylhydroxylamines as the electrophilic nitrogen source.
McDonald's findings are of relevance to medicinal chemistry, drug discovery and materials science. Her thesis is a source of inspiration for scientists entering the field and students beginning their PhD in a related area.
Born and raised in South Carolina, Stacey McDonald completed her B.S. in Chemistry from Wofford College in 2009. She then matriculated into the Chemistry Department at Duke University to pursue her Ph.D. in Organic Chemistry. While at Duke, Stacey's research focused on organic synthesis and methodology development for electrophilic aminations. She successfully defended her Ph.D. in March 2015. Stacey is currently working as a Postdoctoral Fellow at the University of North Carolina - Chapel Hill in the lab of Jeff Aubé.
Born and raised in South Carolina, Stacey McDonald completed her B.S. in Chemistry from Wofford College in 2009. She then matriculated into the Chemistry Department at Duke University to pursue her Ph.D. in Organic Chemistry. While at Duke, Stacey's research focused on organic synthesis and methodology development for electrophilic aminations. She successfully defended her Ph.D. in March 2015. Stacey is currently working as a Postdoctoral Fellow at the University of North Carolina - Chapel Hill in the lab of Jeff Aubé.
Electrophilic amination for the synthesis of alkyl and aryl amines.- Selective α-amination and α-acylation of esters and amides via dual reactivity of O-acylhydroxylamines toward zinc enolates.- Copper-catalyzed α-amination of phosphonates and phosphine oxides: a direct approach to α-amino phosphonic acids and derivatives.- Copper-Catalyzed Electrophilic Amination of Heteroarenes and Arenes by C−H Zincation.
| Erscheint lt. Verlag | 18.8.2016 |
|---|---|
| Reihe/Serie | Springer Theses | Springer Theses |
| Zusatzinfo | XXIII, 144 p. 8 illus. |
| Verlagsort | Cham |
| Sprache | englisch |
| Themenwelt | Naturwissenschaften ► Chemie ► Organische Chemie |
| Technik | |
| Schlagworte | Alpha-Aminophosphonic Acids • Aryl Amines • C–H Functionalization • C–N Bond Formation • Copper-Catalyzed Amination • Electrophilic Amination |
| ISBN-10 | 3-319-38878-9 / 3319388789 |
| ISBN-13 | 978-3-319-38878-6 / 9783319388786 |
| Haben Sie eine Frage zum Produkt? |
PDF (Wasserzeichen)Größe: 7,4 MB
DRM: Digitales Wasserzeichen
Dieses eBook enthält ein digitales Wasserzeichen und ist damit für Sie personalisiert. Bei einer missbräuchlichen Weitergabe des eBooks an Dritte ist eine Rückverfolgung an die Quelle möglich.
Dateiformat: PDF (Portable Document Format)
Mit einem festen Seitenlayout eignet sich die PDF besonders für Fachbücher mit Spalten, Tabellen und Abbildungen. Eine PDF kann auf fast allen Geräten angezeigt werden, ist aber für kleine Displays (Smartphone, eReader) nur eingeschränkt geeignet.
Systemvoraussetzungen:
PC/Mac: Mit einem PC oder Mac können Sie dieses eBook lesen. Sie benötigen dafür einen PDF-Viewer - z.B. den Adobe Reader oder Adobe Digital Editions.
eReader: Dieses eBook kann mit (fast) allen eBook-Readern gelesen werden. Mit dem amazon-Kindle ist es aber nicht kompatibel.
Smartphone/Tablet: Egal ob Apple oder Android, dieses eBook können Sie lesen. Sie benötigen dafür einen PDF-Viewer - z.B. die kostenlose Adobe Digital Editions-App.
Buying eBooks from abroad
For tax law reasons we can sell eBooks just within Germany and Switzerland. Regrettably we cannot fulfill eBook-orders from other countries.
aus dem Bereich
