Biochemistry of Oxidative Stress

Introduction.- Section 1 GENERAL ASPECTS: 1 The concept of oxidative stress after 30 years.- 2 Evolution of atmospheric oxygen and oxygen metabolism.- 3 Mitochondria as origin of cellular oxidative stress.- 4 Biochemistry and physiology of mtNOS.- 5 Biochemistry of nitrogen reactive species.- 6 Biochemistry of nitro fatty acids.- 7 Mammalian adaptation to life at high altitude.- 8 Metabolic syndrome and oxidative stress in rat pancreas.- 9 Progesterone prevents mitochondrial dysfunction and oxidative stress in the spinal cord of wobbler mice.- 10 Mitochondrial transfer by intercellular nanotubes.- Section 2 CARDIOVASCULAR: 11 Role of Oxidative Stress in Subcellular Defects in Ischemic Heart Disease.- 12 Regulation of protein nitrosylation by Trx1.- 13 Inhibition of adenylyl cyclase type 5 increases longevity and healthful aging through oxidative stress protection.- 14 Antioxidant supplementation in elderly cardiovascular patients.- 15 Rupture of redox homeostasis in a model of pulmonary artery.- 16 Mitochondrial reactive oxygen species triggered by the cardiac renin-angiotensin-aldosterone system.- 17 Mitochondrial complex I inactivation and increased autooxidation after ischemia-reperfusion in the stunned heart.- 18 Oxidized LDL and atherogenesis.- 19 Reactive oxygen species and cyclooxygenase products in the regulation of blood flow in small vessels.- 20 Thioredoxin-1 attenuates postischemic ventricular and mitochondrial dysfunctions.- 21 Nitro-arachidonic acid reduces the damaged area in rat myocardial infarction.- 22 Inhaled particulate matter and myocardial dysfunction.- Section 3 NEURODEGENERATION AND NEURONAL FUNCTION: 23 Effect of lipoic acid in the triple transgenic mouse model of Alzhaimer's disease.- 24 Neurovascular coupling mediated by NO in the hippocampus.- 25 Protection from neurodegeneration: signaling and mitocondrial regulation.- 26 Oxidative stress and neurodegeneration.- 27 Oxidative stress, metabolic syndrome and Alzheimer´s disease.- 28 Systemic oxidative stress in patients with neurodegenerative diseases.- Section 4 CANCER: 29 Oxygen metabolism and oxidative stress in cancer cells.- 30 Mitochondrial biogenesis is required for survival and propagation of cancer cells.- 31 Tumor immunology & immunotherapy in patients.- 32 Oncogene-induced Nrf2 repression as adaptive response of cancer cells to acquire a pro-oxidant state favoring cell survival and in vivo tumor growth.- 33 Mitochondrial dynamics regulate oxidative metabolism in Leydig tumor cells.- Index