The Biology of Haematopoiesis

This work presents technical material on recent developments in the field of blood cell production, including the isolation and purification of haematopoietic stem cells and the applications of purified stem cells and recombinant growth factors in bone marrow therapy.

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This work presents technical material on the most recent developments in the field of blood cell production, including the isolation and purification of haematopoietic stem cells, their characteristics in gene transfer and expression, and the applications of purified stem cells and recombinant growth factors in bone marrow therapy. Comprehensive in scope, the book includes reviews of the general history and status of the entire field. Leading researchers and clinicians cover highly specialized topics, including tissue culture systems and cellular requirements for haematopoietic differentiation; growth factor receptors and the molecular and cellular biology of haematopoiesis; gene expression and transfer in haematopoietic stem cells, and regulation of haematopoietic growth factors.There is also a section on the ethics of genetic manipulation in haematopoietic therapy with perspectives from both scientists and the clergy.