Viral Pathogenesis

Dr. Katze is Professor of Microbiology at the University of Washington and Associate Director for Molecular Sciences and Core Staff Scientist at the Washington National Primate Research Center. He has studied virus-host interactions for 35 years and is an international leader in applying systems biology approaches to infectious disease research. He is an author of over 300 papers and reviews, the majority of which are related to the use of high-throughput and computational methods. He has received the Milstein Award from the International Society of Interferon and Cytokine Research, the Dozor Scholar Award from the Israeli Microbiology Society, and is a Fellow of the American Academy of Microbiology. Dr. Korth is a Senior Research Scientist in the Department of Microbiology at the University of Washington. He specializes in technical and medical writing and the effective communication of scientific concepts in grants, contracts, and the professional literature. He is a member of the American Medical Writers Association and holds a BA in psychology from the University of Wisconsin-Eau Claire, a BS in microbiology and BSMT in medical technology from the University of Montana, and a PhD in microbiology from the University of Washington. His research interests are in the use of systems biology approaches to study viral pathogenesis. Dr. Law is a Senior Research Scientist in the Department of Microbiology at the University of Washington. Her research interests are in the use of high-throughput and computational approaches to study virus-host interactions. She has managed several large programs that utilize different animal models, high-throughput technologies such as microarray and RNS-seq assays, and computational approaches to define the host response to a variety of viruses including influenza, SARS, MERS, and SIV. The overarching goal of these studies is to identify host targets for therapeutic interventions. She holds a BA in chemistry from the University of Colorado and a PhD in biochemistry from Washington State University. Neal Nathanson is emeritus Professor of Microbiology at the University of Pennsylvania. He has spent most of his 50-year career working on the pathogenesis of a wide variety of viral infections, using animal models to investigate the viral and host determinants of disease. He edited the prior two editions of Viral Pathogenesis.

Viral Pathogenesis: From Basics to Systems Biology

1. The Human Toll of Viral Diseases: Past plagues and pending pandemics

Neal Nathanson

2. Historical Roots: The family tree of viral pathogenesis

William C. Summers

3. Basic Concepts: A step-by-step guide to viral infection

Robert Doms

4. Innate Immunity: Recognizing and responding to foreign invaders—no training needed

Christine A. Biron

5. Adaptive Immunity: Neutralizing, eliminating, and remembering for the next time

E. John Wherry, David Masopust

6. Aberrant Immunity: The consequences of overreacting or underperforming

E. John Wherry, David Masopust

7. Patterns of infection: Unwanted guests—quick visits and extended stays

Neal Nathanson and Francisco González-Scarano

8. Viral Oncogenesis: Infections That Can Lead to Cancer

Nicholas A. Wallace and Denise A. Galloway

9. HIV and AIDS: Science wrestles with 10,000 nucleotides—points but no pin

Guido Silvestri and Emily Cartwright

10. Animal Models: No model is perfect, but many are useful

Victoria K. Baxter and Diane E. Griffin

11. Systems Virology: Why Everybody Wants To Measure Everything

Marcus J. Korth and G. Lynn Law

12. The Virus-Host Interactome: Knowing the players to understand the game

Monika Schneider, Jeffery R. Johnson, Nevan J. Krogan, and Sumit K. Chanda

13. Host Genetics: It’s not just the Virus, Stupid

Martin T. Ferris, Mark T. Heise, and Ralph S. Baric

14. Host metabolomics: Yet more ways your health is influenced by fat

Priscilla Yang

15. Mathematical Modeling: Solving equations to measure viral diseases – math rules

Alan S Perelson

16. Emerging viral diseases: Why we need to worry about bats, camels, and airplanes

James W. Le Duc and Neal Nathanson

17. Viral evolution: It’s all about mutations

Adi Stern and Raul Andino

18. Viral Epidemiology: Tracking viruses with smartphones and social media

Kaitlin Rainwater-Lovett, Isabel Rodriguez-Barraquer and William J. Moss

19. Viral Vaccines: Fighting viruses with viruses

Juliet Morrison and Stanley Plotkin

20. Antiviral Therapy

Douglas D. Richman and Neal Nathanson

21. Breakthrough: Nobel prize discoveries in viral pathogenesis

Neal Nathanson

22. What lies ahead? Scientists look into their crystal balls