Metabolism and Bacterial Pathogenesis

Tyrrell was born in Bartlesville, Oklahoma, and is married for 29 years to Sharri Conway, an elementary school teacher. They have two children. Tyrrell graduated from Oklahoma State University with a doctorate in Microbiology. He held faculty appointments at the University of Florida, University of Nebraska, Ohio State University, the University of Oklahoma, and currently is Professor and Head of Department of Microbiology and Molecular Genetics at Oklahoma State University. Amongst several scientific discoveries Tyrrell is the co-inventor of U.S. Patent number 5,000,000 for genetically engineering E. coli to make biofuels and published the first DNA microarray paper on E. coli. He and Paul Cohen were the first scientists to systematically determine what carbon sources are used by E. coli to colonize the animal intestine. Tyrrell is a member of the American Academy of Microbiology. If he had time, he would read more novels and go fishing more often. Paul Cohen was born in Boston, Massachusetts and earned his A.B. in General Science at Brandeis University in Waltham, MA in 1960 and his A.M. in Biology in 1962 and his Ph.D. in Biology in 1964 at Boston University in Boston, MA. He did his Post-Doctoral work at St. Jude Children's Research Hospital in Memphis, TN from 1964-1966. In 1966 he joined the Department of Bacteriology (now the Department of Cell and Molecular Biology) at the University of Rhode Island and retired this year. From 1964-1978 he studied regulation of RNA and protein synthesis in bacteriophage T4 infected E. coli, from 1978-1983 he studied regulation of RNA and protein synthesis in Vesicular Stomatitis Virus infected Chinese Hamster Ovary cells, and from 1983-present, he's studied how E. coli colonizes the large intestines of mice. He's served on the editorial boards of Antimicrobial Agents and Chemotherapy, The European Journal of Clinical Microbiology, and Infection and Immunity. He spent Sabbaticals at MIT, at Ciba-Geigy in Basel, Switzerland, at The University of Goteborg in Goteborg, Sweden, and at The Danish Technical University in Lyngby, Denmark. He's consulted for Bayer Corp., Wuppertal, Germany, Hoffmann-LaRoche, Inc., Nutley, NJ, Ciba-Geigy Ltd, Basel, Switzerland, and Intervet International, Boxmeer, The Netherlands. He is married to Catherine Trebino, a Research Associate at Brown University and has three children. Recently (2005), he co-edited a book entitled Colonization of Mucosal Surfaces (ASM Press), with James Nataro, Harry Mobley, and Jeffrey Weiser

Contributors


Preface


1 Glycolysis for the Microbiome Generation
2 Pathogenesis - Thoughts from the Front Line
3 Metabolic Adaptations of Intracellullar Bacterial Pathogens and their Mammalian Host Cells during Infection ("Pathometabolism")
4 Small RNAs Regulate Primary and Secondary Metabolism in Gram-negative Bacteria
5 Sialic acid and N-acetylglucosamine Regulate type 1 Fimbriae Synthesis
6 Trigger Enzymes: Coordination of Metabolism and Virulence Gene Expression
7 Regulating the Intersection of Metabolism and Pathogenesis in Gram-positive Bacteria
8 Borrelia burgdorferi: Carbon Metabolism and the Tick-Mammal Enzootic Cycle
9 Metabolism and Pathogenicity of Pseudomonas aeruginosa Infections in the Lungs of Individuals with Cystic Fibrosis
10 Metabolism and Fitness of Urinary Tract Pathogens
11 Bacterial Metabolism in the Host Environment: Pathogen Growth and Nutrient Assimilation in the Mammalian Upper Respiratory Tract
12 Saliva as the Sole Nutritional Source in the Development of Multispecies Communities in Dental Plaque
13 Enteric Pathogens Exploit the Microbiota-generated Nutritional Environment of the Gut
14 The Roles of Inflammation, Nutrient Availability and the Commensal Microbiota in Enteric Pathogen Infection
15 Host Sialic Acids: A Delicacy for the Pathogen with Discerning Taste
16 Commensal and Pathogenic Escherichia coli Metabolism in the Gut 343


Index