Neuropeptide Systems as Targets for Parasite and Pest Control

TIMOTHY G. GEARY is a Tier I Canada Research Chair and is Professor and Director of the Institute of Parasitology at McGill University in Montréal, Québec, Canada. Geary received a BSc degree from the University of Notre Dame in South Bend, IN (USA) and a PhD in Pharmacology from the University of Michigan in Ann Arbor, MI (USA, 1980). He worked on malaria chemotherapy at Michigan State University in East Lansing, MI (USA) until 1985, when he joined The Upjohn Company in Kalamazoo, MI (USA) as a staff scientist working on discovery of antiparasitic drugs. Geary joined the Faculty at McGill in 2005; research interests include proteomics and genomics analyses of the host-parasite interface, discovery of anthelmintics and the pharmacology of antiparasitic drugs. AARON G. MAULE is a Director of Research for Molecular Biosciences and Professor of Molecular Parasitology at Queen’s University Belfast, Northern Ireland. Maule was awarded a BSc(Hons) in Biology (1986) and a PhD in Experimental Parasitology (1989) at Queen’s where he began working on parasite neuromuscular systems. He focused on molecular aspects of parasite neurobiology during postdoctoral positions at Queen’s and at The Upjohn Company in Kalamazoo, MI (USA). Maule returned to Queen’s as a member of academic staff in 1995 to pursue the basic biology of helminth signaling systems. Research interests include parasite neurobiology and the development and exploitation of gene silencing platforms for target validation and parasite control.

Receptor-Based Discovery Strategies for Insecticides and Parasiticides: A Review.- Nonpeptide Ligands for Peptidergic G Protein-Coupled Receptors.- Interaction of Mimetic Analogs of Insect Kinin Neuropeptides with Arthropod Receptors.- Neuropeptides in Helminths: Occurrence and Distribution.- Neuropeptide Physiology in Helminths.- Neuropeptide Gene Families in Caenorhabditis elegans.- Control of Nematode Parasites with Agents Acting on Neuro-Musculature Systems: Lessons for Neuropeptide Ligand Discovery.- Neuropeptide Signaling in Insects.- Neuropeptide Physiology in Insects.- Neuropeptide Biology in Drosophila.- Neuropeptide Receptors as Possible Targets for Development of Insect Pest Control Agents.