The Eukaryotic Replisome: a Guide to Protein Structure and Function

1. Composition and dynamics of the eukaryotic replisome: a brief overview. - 2. Evolutionary diversification of eukaryotic DNA replication machinery. - 3. The origin recognition complex: a biochemical and structural view. - 4. Archaeal Orc1/Cdc6 Proteins. -5. Cdt1 and Geminin in DNA replication initiation. - 6. MCM structure and mechanics: what we have learned from archaeal MCM. - 7. The Eukaryotic Mcm2-7 Replicative Helicase. - 8. The GINS complex: structure and function. - 9. The Pol α-primase complex. - 10. The structure and function of replication protein A in DNA replication. - 11. Structural biology of replication initiation factor Mcm10. - 12. Structure and function of eukaryotic DNA polymerase d. - 13. DNA polymerase ε. - 14. The RFC clamp loader: structure and function. - 15. PCNA structure and function: insights from structures of PCNA complexes and post-translationally modified PCNA. - 16. The wonders of Flap Endonucleases: structure, function, mechanism and regulation. - 17.  DNA ligase I, the replicative DNA ligase