Creatine

I. Creatine: Biochemical Aspects.- Creatine-Phosphocreatine Pathway in the Intracellular Networks of Energy Transfer and Signal Transduction in Muscle Cells.- Guanidinoacetate Methyltransferase (GAMT) Deficiency, the First Inborn Error of Creatine Metabolism.- II. Physiology and Physiopathology.- A Physiological View of The Creatine-Phosphate Shuttle, Exercise, and Protein Synthesis.- Creatine in Cardiovascular Metabolism During Physiological and Pathological Conditions: NMR Studies.- III. Role of Creatine in the Clinical Practice.- Effects and Safety of Dietary and Supplementary Creatine.- Creatine Supplementation in Patients with Chronic Heart Failure.- Creatine in Sports Medicine: Nutritional Supplementation and/or Medicinal Product?.- IV. Use of Creatine in Sports Medicine.- Physiological Role of Creatine in Muscle Metabolism During Exercise.- Impact of Oral Creatine Supplementation on Muscle Performance During Training and Rehabilitation.- Factors Modifying Creatine Accumulation in Human Skeletal Muscle.- V. Use of Creatine: New Potential Applications.- New Areas for Creatine Supplementation: Chronic Obstructive Pulmonary Disease and Geriatric Conditions.- Creatine Supplementation in Mitochondrial Cytopathies.- The Neuroprotective Properties of Creatine in Animal Models of Neurodegenerative Diseases.