Antimicrobial susceptibility patterns and proportions of Escherichia coli in urinary tract infections in Mansehra, Pakistan

Research Paper (postgraduate) from the year 2013 in the subject Biology - Micro- and Molecular Biology, grade: A, , language: English, abstract: Urinary tract infections are the most common bacterial infections globally, caused by Escherichia coli. Escherichia coli produces an enzyme called extended spectrum beta-lactamases (ESBL) which inhibits penicillins, cephalosporins and various other antibiotics. The current study included 1720 specimens, isolated from urine samples of inpatients and outpatients suffering from Urinary tract infections. The antimicrobial susceptibility by disc diffusion was performed on each isolate by using 10 antibiotics according to Clinical Laboratory Standards Institute (CLSI) criteria. 370 (21.5%) specimens were confirmed to be E.coli isolates. E.coli isolates were found to be 97.2% sensitive against Imipenem, 96.4% against Meropenem, 50.0% against Gentamicin, 47.2% against Kanamycin, 38.3% against Ciprofloxacin, 15.6% against Doxycycline, and 25.6% sensitive against Co-trimoxazole. A large proportion of E.coli isolates were found to be multi drug resistant. E.coli isolates were found to be 91.8% resistant against Ampicillin, 84.3% against Doxycycline, 82.4% against Cefaclor, and 80.5% resistant against Nalidixic Acid.