Regulation of Immune Gene Expression

A. Molecular Basis of MHC.- Structure/Function Relationships Among Murine Class II Molecules: Sequence Analysis of l-A cDNA Clones.- Organization and Evolution of Mouse Major Histocompatibility Genes.- Gene Organization and Recombination Hot Spots in the Murine Major Histocompatibility Complex.- Molecular Genetics of Human la Antigens.- Polymorphism in the HLA-D Region.- Biochemical Diversity of the Human MHC Class II Antigens.- B. Molecular Basis of Lymphocyte Activation.- The T-Cell Receptor/T3 Complex.- Structure and Regulation of the Genes Encoding lnterleukin-2 and Its Receptor.- Activation of Precursor and Mature T Lymphocytes via the 50 kD T11 Molecule.- Functional Characterization of Several Steric Domains of the Murine Thy-1 and LFA-1 Molecules.- Interactions Between Protein Kinase C and the T3/T Cell Antigen-Receptor Complex.- C. Molecular Analysis of T Cell Receptors.- Murine T-Cell Receptor Genes and the Problems of Cellular Recognition and Repertoire Selection.- Organization and Expression of Human T-Cell Receptor Genes.- A Fusion Gene of Immunoglobulin and T-Cell Receptor DNA Segments in a Chromosome 14 Inversion of T-Cell Leukemia.- Diversity of T-Cell Receptor Structures Specific for Minimal Peptide/la Determinants: Implications for Immune Response Gene Defects.- A Chromosomal Inversion Generates a Functional T Cell Receptor ? Chain Gene.- D. Antigen Presentation.- Accessory Cells and the Activation and Expression of Different T Cell Functions.- HLA-Linked Immune Suppression Gene Maps Within HLA-DQ Subregion.- Processing and Presentation by Dendritic Cells—The Role of the Lysosome in Antigen Breakdown.- Recognition of Nucleoprotein by Influenza-Specific CTL.- Structural and Conformational Requirements for Ir-Gene-Controlled Myoglobin EpitopeRecognition by la-Restricted T Cells and Clones.- E. Hla and Disease.- HLA in Transplantation.- Class III HLA Genes and Systemic Lupus Erythematosus.- HLA-D Region Expression on Thyrocytes: Role in Stimulating Autoreactive T Cell Clones.- F. T Cell Repertoire.- T-Cell Repertoire Tuning by the MHC in Protection Against Lethal Vims Infection and in Rejection of H-Y Disparate Skin Grafts.- The Influence of the Molecular Context of T-Cell Determinants and the Non-MHC Genetic Context of the H-2b Genes on the Immunogenicity of Lysozyme.- Differential Expression of HLA-DR and DQ Molecules on Activated T Lymphocytes.- Interactions of Majors and Minors as Seen by T-Cells and Other Spectators.- Workshop Summaries.- Relationship of Idiotypes and MHC Networks.- The Relationship of T-Cell Receptors and Factors.- T-B Cell Interactions.- Regulation of Antigen Presentation and T Cell Subsets.- Transfection of MHC Genes.- Tolerance and Development of T Cell Repertoire.