In Vitro Toxicity Testing of Environmental Agents

A: Survey of Test Systems.- I. Mutagenesis Testing: Prokaryotic Systems.- Molecular Mechanisms of Mutagenesis and Chromosomal Carcinogenesis: A Suimnary Review.- Molecular Principles Underlying the Ames Salmonella/Microsome Test: Elements and Design of Short-Term Mutagenesis Tests.- Bacillus subtilis Rec-Assay With and Without Metabolic Activation: Improvements and Applications.- A Simple, Forward Selection Scheme for Independently Determining the Toxicity and Mutagenic Effect of Environmental Chemicals: Measuring Replica- tive Killing of Escherichia coli by an Integrated Fragment of Bacteriophage Lambda DNA.- The Use of Salmonella Bacteriophage P22 To Study the Multiple Mechanisms of Acridine-Induced Damage.- II. Mutagenesis Testing: Eukaryotic Systems.- Use of a Ciliated Protozoan as a Model System To Detect Toxic and Carcinogenic Agents.- In Vivo Assay To Screen for Mutagens/Carcinogens in the Nematode C. elegans.- The Maize-Microbe Bioassay: A Unique Approach to Environmental Mutagenesis.- Mutagenicity of Ambient Air at Selected Sites in the United States Using Tradescantia as a Monitor.- Tradescantia Micronuclei (TRAD-MCN) Test for Environmental Clastogens.- Metabolic Activation and Mutagenic Properties of Procarcinogens in Drosophila.- Mammalian Cell Mutagenesis: Relevance for Detection of Environmental Mutagens/Carcinogens.- Quantitative Mammalian Cell Mutagenesis and Mutagen Screening: Study With Chinese Hamster Ovary Cells.- III. In Vitro Carcinogenesis Testing.- In Vitro Carcinogenesis With Cell Lines.- Modulation of Induced Quantitative Mammalian Cell Transformation.- Chemical Carcinogenesis In Vitro: Limitations and Possibilities in the Use of Rat Liver Epithelial Cells for Screening Carcinogens.- IV. Neurobehavioral Toxicity Testing.- Behavioral Assays in environmental Toxicology.- Prenatal Exposure to Environmental Chemicals as a Test System for Neurotoxicology.- Mechanisms in Heavy Metal Toxicity.- Use of Cultures of Neuroblastoma and Glioma as a Model System To Study the Heavy Metal-Induced Neurotoxicity.- Neurochemical Approaches to Toxicity Testing: Artificial Food Dyes.- In Vitro Approaches to Neurotoxicity--A Physiologist’s Perspective.- V. End-Organ Toxicity Testing.- Migration Inhibition of Alveolar Macrophages: An Assay System for Evaluating Toxicity of Pollutant Chemicals.- Environmental Factors in Renal Disease.- Indexes (Combined for Part A and Part B volumes).- Author Index.