Technical Advances in AIDS Research in the Human Nervous System

New Concepts in the Pathogenesis of HIV-1 Encephalopathy.- 1. HIV Encephalopathy: Clinical and Diagnostic Considerations.- 2. Cellular and Molecular Pathology of Novel Cerebral Diseases in AIDS.- 3. Peripheral Neuropathy in AIDS: New Investigative Approaches.- Models of HIV-1 Infection and Neurotoxicity in the Human Fetal Nervous System.- 4. Overview: Models of HIV-1 Infection and Neurotoxicity in the Human Fetal Nervous System.- 5. HIV-1-Derived Neurotoxic Factors: Effects on Human Neuronal Cultures.- 6. Experimental Model Systems for Studies of HIV Encephalitis.- 7. Cell Cultures from Human Fetal Brain Provide a Model for HIV-1 Persistence and Reactivation in the Central Nervous System.- 8. Use of Human Brain Cell Aggregates for AIDS Research in the Nervous System.- 9. Infection of Human Fetal Astrocytes with HIV.- Model Cell Cultures from Adult Brain and Glioma Cell Lines.- 10. Molecular Interaction of HIV-1 in Glioma Cells.- 11. Transcription of Human Immunodeficiency Virus Promoter in CNS-Derived Cells: Effect of TAT on Expression on Viral and Cellular Genes.- 12. Tumor Necrosis Factor Alpha Derived from Human Microglia Enhances HIV-1 Replication and Is Toxic for Rat Oligodendrocytes in Vitro.- 13. Nitric Oxide Mediates a Component of gp120 Neurotoxicity in Primary Cortical Cultures.- Neurotropism of HIV-1 Strains.- 14. Contribution of V3 and Reverse Transcriptase Sequence Analysis to Understanding the Concept of HIV-1 Neurotropism.- 15. Sequence Analysis of Neuroinvasive and Blood-Derived HIV-1 nef Genes.- 16. An Organ Model for HIV Infection of the Blood-Brain Barrier.- 17. The Role of the Astrocyte in the Pathogenesis of the AIDS Dementia Complex.- 18. Alternative Receptors for HIV-1 in Nervous System Tissues.- Molecular Technology for the Detection and Analysisof HIV-1 in Nervous System Tissue.- 19. Detection of HIV-1 Gene Sequences in Brain Tissue by in Situ Polymerase Chain Reaction.- 20. The Utility of PCR in Situ Hybridization for the Detection of HIV-1 DNA and RNA.- 21. Electrochemiluminescence-Based Detection System for the Quantitative Measurement of Antigens and Nucleic Acids: Application to HIV-1 and JC Viruses.- Development of New Techniques and Methods Applied to Aids.- 22. Techniques in PCR and PCR Evaluation Technology and Its Application to the Study of Cerebrospinal Fluid in HIV Disease.- 23. Quantification of Quinolinic Acid Metabolism of Macrophages and Astrocytes.- 24. Targeted Defective Interfering HIV-1 Particles as Renewable Antivirals?.- Focus on Aids and the Nervous System: Challenges during the Decade of the Brain.- 25. Treatment of Neurological Complications in AIDS: The AIDS Clinical Trials Group in the 1990s.- 26. Technical Advances and the Challenge of HIV-1 Related Neurological Diseases.- Contributors.