Basic Biology and Clinical Impact of Immunosenescence (eBook)

Cover 1
Table of Contents 6
Preface 8
Chapter 1. The OCTO and NONA Immune Longitudinal Studies: A Review of 11 years Studies of Swedish very old humans 12
Chapter 2. Immune Measures which Predict 9-Year Survival in an Elderly Population Sample 28
Chapter 3. Immunological and Immunogenetic Markers of Successful and Unsuccessful Ageing 40
Chapter 4. Developmental Aspects of the Thymus in Aging 58
Chapter 5. Effective Immunity During Late Life A Possible Role for the Thymus
Chapter 6. Alterations in Signal Transduction in T Lymphocytes and Neutrophils with Ageing 104
Chapter 7. CD28 Downregulation and Expression of NK-Associated Receptors on T Cells in Aging and Situations of Chronic Activation of the Immune System 134
Chapter 8. Characterisation of NK Cells in the Elderly 144
Chapter 9. T Cell Ageing and Immune Surveillance 170
Chapter 10. A Road to Ruins: An Insight Into Immunosenescence 184
Chapter 11. Genetic Damage and Ageing T Cells 202
Chapter 12. Role of DNA-dependent Protein Kinase (DNA-PK), A Protein with Multiple Intracellular Functions, in Cells of the Ageing Immune System 228
Chapter 13. Linker Histone H1o Gene Expression During Ageing and After the Effect of Histone Deacetylase Inhibitors in Human Diploid Fibroblasts and T Lymphocytes 242
Chapter 14. Zinc and the Immune System of Elderly 254
Chapter 15. Altered Zinc Binding by Metallothioneins in Immune-Neuroendocrine Senescence: A Vicious Circle Between Metallothioneins and Chaperones? 272
Chapter 16. T Cell Exhaustion and Aging: Is Replicative Senescence Relevant? 294
Chapter 17. Cultured T cell Clones as Models for Immunosenescence 306
Contributor Addresses 320